{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:21Z","timestamp":1753862841639,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The Japanese Interventional oncology group (JIVROSG) showed the efficacy and safety of nonselective transarterial chemoembolization (TACE) with fine cisplatin powder (diamminedichloroplatinum; DDP\u2010H) (65\u2009mg\/m<jats:sup>2<\/jats:sup>) and porous gelatin particles (DDP\u2010H TACE) without lipiodol for extensive multifocal hepatocellular carcinoma (HCC). However, there are no studies on this method following the JIVROSG study. Therefore, we aimed to evaluate the efficacy of this new DDP\u2010H TACE and its effect on liver function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the medical records of TACE\u2010na\u00efve patients with multifocal HCC (Child\u2010Pugh class A, up\u2010to\u2010seven out, no prior history of systemic therapy) who underwent whole\u2010liver DDP\u2010H TACE between January 2006 and December 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty patients were included in this study. The median age of the patients was 71 (range, 35\u201388) years. The median maximum size of tumors was 26 (range, 8\u2013184) mm; 86.7% of patients met the up\u2010to\u201011 criteria out. The overall survival duration was 30.3\u2009months. At the time of initial evaluation (median, 45\u2009days), the overall response rate was 65.0%; the disease control rate was 86.7% based on the modified response evaluation criteria in solid tumors guideline. Although nine patients' liver function had deteriorated to Child\u2010Pugh class B at initial evaluation, six of them recovered to Child\u2010Pugh class A. Only three patients (5%) showed permanently impaired liver function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Whole\u2010liver DDP\u2010H TACE without lipiodol or beads effectively reduced tumors and preserved liver function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7446","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T07:25:24Z","timestamp":1721201124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["No lipiodol, no beads\u2014another transcatheter arterial chemoembolization (<scp>TACE<\/scp>) with fine cisplatin powder and porous gelatin particles for <scp>TACE<\/scp>\u2010na\u00efve, multifocal, up\u2010to\u2010seven out hepatocellular carcinoma"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0230-7471","authenticated-orcid":false,"given":"Rui","family":"Sato","sequence":"first","affiliation":[{"name":"Division of Interventional Radiology Shizuoka Cancer Center  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michihisa","family":"Moriguchi","sequence":"additional","affiliation":[{"name":"Molecular Gastroenterology and Hepatology Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-1119","authenticated-orcid":false,"given":"Atsushi","family":"Saiga","sequence":"additional","affiliation":[{"name":"Division of Interventional Radiology Shizuoka Cancer Center  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Asahara","sequence":"additional","affiliation":[{"name":"Division of Interventional Radiology Shizuoka Cancer Center  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Aramaki","sequence":"additional","affiliation":[{"name":"Division of Interventional Radiology Shizuoka Cancer Center  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29913"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.019"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000507370"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11081084"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-009-0234-z"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2012.06.028"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9289321"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8350926"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13550"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13048"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-009-9781-6"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-012-0088-1"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00392"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.7446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T22:46:10Z","timestamp":1744929970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.7446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":13,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/cam4.7446"],"URL":"https:\/\/doi.org\/10.1002\/cam4.7446","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"type":"print","value":"2045-7634"},{"type":"electronic","value":"2045-7634"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7446"}}