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Most employed salvage treatments included platinum salt\u2010based regimens in 38\/134 (28.4%), lenalidomide in 14 (10.4%). Median OS and PFS after disease relapse or progression (OS\u20102 and PFS\u20102) were 6.7 and 5.1\u2009months respectively. No significant difference in overall response rate, OS\u20102 or PFS\u20102 in patients treated with platinum\u2010based regimens versus other regimens was observed. By multivariate analysis, age between 60 and 80\u2009years, germinal center B cell type cell of origin and extranodal involvement of &lt;2 sites were associated with better OS\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our findings confirm very poor outcomes of R\/R DLBCL in the rituximab era. Widespread approval by national Medicine Agencies of novel treatments such as CAR\u2010T cells and bispecific antibodies as second\u2010line is eagerly awaited to improve these outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7448","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T08:30:17Z","timestamp":1721377817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Real life clinical outcomes of relapsed\/refractory diffuse large B cell lymphoma in the rituximab era: The <scp>STRIDER<\/scp> study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0873-1622","authenticated-orcid":false,"given":"Irene","family":"Dogliotti","sequence":"first","affiliation":[{"name":"Division of Hematology University Hospital A.O.U. \u201cCitt\u00e0 della Salute e della Scienza\u201d  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Peri","sequence":"additional","affiliation":[{"name":"Division of Hematology University Hospital A.O.U. \u201cCitt\u00e0 della Salute e della Scienza\u201d  Turin Italy"},{"name":"Division of Hematology U, Department of Molecular Biotechnologies and Health Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Clerico","sequence":"additional","affiliation":[{"name":"Division of Hematology University Hospital A.O.U. \u201cCitt\u00e0 della Salute e della Scienza\u201d  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Vassallo","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedale Santa Croce e Carle  Cuneo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Musto","sequence":"additional","affiliation":[{"name":"Division of Hematology U, Department of Molecular Biotechnologies and Health Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Mercadante","sequence":"additional","affiliation":[{"name":"Division of Hematology U, Department of Molecular Biotechnologies and Health Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ragaini","sequence":"additional","affiliation":[{"name":"Division of Hematology University Hospital A.O.U. \u201cCitt\u00e0 della Salute e della Scienza\u201d  Turin Italy"},{"name":"Division of Hematology U, Department of Molecular Biotechnologies and Health Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Botto","sequence":"additional","affiliation":[{"name":"Division of Hematology AOU \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Levis","sequence":"additional","affiliation":[{"name":"Division of Radiotherapy, Department of Oncology. 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