{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:18:37Z","timestamp":1791235117250,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sarcopenic obesity (SO) in patients with gastrointestinal cancer is associated with a poor prognosis. We aimed to investigate the prognostic impact of SO in patients with gastrointestinal cancer, as well as the diagnostic cut\u2010off value of SO in patients with gastrointestinal cancer among Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a consecutive cohort study. Between January 2017 and January 2019, 289 patients diagnosed with gastrointestinal cancer were included in our study. Skeletal muscle area, total fat area, and subcutaneous fat area were measured by CT scan. All patients were followed up for 5\u2009years. Receiver operating characteristic curves (ROC) were adopted to determine the cut\u2010off values of visceral fat obesity for the prediction of sarcopenia. Based on the cut\u2010off values, patients with sarcopenia combined with visceral fat obesity were divided into the SO group, and the others were divided into the non\u2010sarcopenic obesity (NSO) group. Kaplan\u2013Meier curves and univariate and multivariate Cox proportional hazard models were employed to explore the associations of body composition profiles with 5\u2010year overall survival and disease\u2010specific survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Obtained from Youden's Index for ROC for the prediction of 5\u2010year survival, skeletal muscle mass index (SMI) \u226440.02\u2009cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup> with VFA\u2009\u2265\u2009126.30\u2009cm<jats:sup>2<\/jats:sup> in men and SMI \u226432.05\u2009cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup> with VFA \u226572.42\u2009cm<jats:sup>2<\/jats:sup> in women indicate a risk of poor prognosis in patients diagnosed with gastrointestinal cancer. Patients with SO had poorer 5\u2010year overall survival (OS) than patients with NSO (6.74% vs. 82.84%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and poorer 5\u2010year DFS (6.74% vs. 81.82%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In multivariate analysis, we found that the long\u2010term mortality risk was approximately 13\u2010fold higher among patients in the SO group compared to those with no conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative assessment of SO is useful not only for monitoring nutritional status but also for predicting 5\u2010year OS in gastrointestinal cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7452","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T11:00:53Z","timestamp":1719918053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The role of sarcopenic obesity for the prediction of prognosis of patients with gastrointestinal cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Wenqing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinggang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of General Surgery Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing Jiangsu 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