{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:42Z","timestamp":1786977342011,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Abstract<\/jats:title>\n \n Gastrointestinal follicular lymphoma (\n GI<\/jats:styled-content>\n \u2010\n FL<\/jats:styled-content>\n ) is a rare extranodal variant of follicular lymphoma (\n FL<\/jats:styled-content>\n ) that has been increasingly reported in the literature. An especially indolent course is linked to the disease after a lack of observed patient death in past studies. However, overall survival (\n OS<\/jats:styled-content>\n ) and associated prognostic factors remain unclear. A large population\u2010based database was utilized to identify demographic and clinicopathologic characteristics of\n GI<\/jats:styled-content>\n \u2010\n FL<\/jats:styled-content>\n , along with survival differences among primary sites. The Surveillance, Epidemiology, and End Results Registry was used to identify\n GI<\/jats:styled-content>\n \u2010\n FL<\/jats:styled-content>\n cases between the years of 1973 and 2012. Kaplan\u2013Meier curves compared\n OS<\/jats:styled-content>\n differences and Cox proportional hazard models analyzed prognostic factors. Final analysis included 1109 cases. Small intestinal cases, which included those with single\u2010site and multi\u2010segment involvement, were most common (63.6%) followed by gastric (18.2%) and colorectal cases (18.2%). Small intestinal\n GI<\/jats:styled-content>\n \u2010\n FL<\/jats:styled-content>\n presented more frequently with grade I histology, and less often with grade\n III<\/jats:styled-content>\n histology (\n P<\/jats:italic>\n \u00a0<\u00a00.001 and\n P<\/jats:italic>\n \u00a0<\u00a00.001, respectively). Small intestinal cases had better outcomes (5\u2010year\n OS<\/jats:styled-content>\n \u00a0=\u00a080.9%,\n P<\/jats:italic>\n \u00a0<\u00a00.001) compared to cases involving the stomach (5\u2010year\n OS<\/jats:styled-content>\n \u00a0=\u00a052.7%) and colorectum (5\u2010year\n OS<\/jats:styled-content>\n \u00a0=\u00a071.5%). On multivariate analysis for predictors of mortality, small intestinal involvement predicted for better survival; hazard ratio (\n HR<\/jats:styled-content>\n ) 0.66 (95%\n CI<\/jats:styled-content>\n : 0.51\u20130.85). Advanced age (\u226566), grade (grade\n III<\/jats:styled-content>\n ), and stage (Ann Arbor Stage\n III<\/jats:styled-content>\n \/\n IV<\/jats:styled-content>\n ) predicted for mortality with\n HR<\/jats:styled-content>\n 5.46 (95%\n CI<\/jats:styled-content>\n : 3.80\u20137.84), 1.42 (95%\n CI<\/jats:styled-content>\n : 1.10\u20131.83), 1.57 (95%\n CI<\/jats:styled-content>\n : 1.15\u20132.16), respectively.\n GI<\/jats:styled-content>\n \u2010\n FL<\/jats:styled-content>\n has poorer outcomes than previously suggested. Small intestinal involvement has a better prognosis. A possible biological basis for this will require further investigations in the future.\n <\/jats:p>","DOI":"10.1002\/cam4.763","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T09:03:07Z","timestamp":1475830987000},"page":"2669-2677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Gastrointestinal follicular lymphoma: using primary site as a predictor of survival"],"prefix":"10.1002","volume":"5","author":[{"given":"Jay","family":"Chouhan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine The University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology and Nutrition The University of Texas Health Science Center at Houston Houston 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