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The cell proliferation and viability of human tongue cancer cells, SCC<\/jats:styled-content>25 and SCC<\/jats:styled-content>9 cells, were determined by cell counting and MTT<\/jats:styled-content> assay, respectively. The effect of RNF<\/jats:styled-content>126 on regulating AKT<\/jats:styled-content> signaling pathway was analyzed through western blotting. The transplantation tumor model of nude mice was used to evaluate the tumorigenecity of RNF<\/jats:styled-content>126. Knockdown of RNF<\/jats:styled-content>126 inhibited the proliferation and viability of SCC<\/jats:styled-content>9 and SCC<\/jats:styled-content>25 cells. Inhibition of RNF<\/jats:styled-content>126 also decreased the activity of AKT<\/jats:styled-content>1 as well as its downstream molecules. Furthermore, RNF<\/jats:styled-content>126 regulated the tumor volume on mice model. These data suggested that RNF<\/jats:styled-content>126 might be related to the progression of tongue cancer through regulating AKT<\/jats:styled-content> signaling pathway.<\/jats:p>","DOI":"10.1002\/cam4.771","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T15:43:03Z","timestamp":1464277383000},"page":"2043-2047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["E3 Ubiquitin ligase RNF126 regulates the progression of tongue cancer"],"prefix":"10.1002","volume":"5","author":[{"given":"Lina","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endodontics College of Stomatology Dalian Medical University Dalian 116044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan 430072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endodontics College of Stomatology Dalian Medical University Dalian 116044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Endodontics College of Stomatology Dalian Medical University Dalian 116044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endodontics College of Stomatology Dalian Medical University Dalian 116044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yin","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan 430072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endodontics College of Stomatology Dalian Medical University Dalian 116044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.67.1.425"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2780"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1295"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07249.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.03.045"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.645978"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18566"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214538110"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.116129"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.12.020"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.18632\/oncotarget.6395","article-title":"Negative\u00a0correlation of ITCH E3 ubiquitin ligase\u00a0and\u00a0miRNA\u2010106b dictates metastatic progression\u00a0in pancreatic cancer","volume":"7","author":"Luo Z. 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