{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:33:59Z","timestamp":1784349239208,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to investigate the impact of treatment time\u2010related factors on outcomes and radiation proctitis in patients undergoing concurrent chemoradiotherapy (<jats:styled-content style=\"fixed-case\">CCRT<\/jats:styled-content>) for cervical cancer. From September 2001 to December 2012, 146 patients with stage <jats:styled-content style=\"fixed-case\">IIB<\/jats:styled-content> cervical squamous cell carcinoma treated with <jats:styled-content style=\"fixed-case\">CCRT<\/jats:styled-content> were reviewed from a prospective cohort. Patients who received the same dose (45\u00a0Gy) of external beam radiation therapy (<jats:styled-content style=\"fixed-case\">EBRT<\/jats:styled-content>) were included in the analysis (<jats:italic>n<\/jats:italic>\u00a0=\u00a0125). The same equivalent dose of 2\u00a0Gy (<jats:styled-content style=\"fixed-case\">EQD<\/jats:styled-content>2) of high\u2010dose\u2010rate intracavitary brachytherapy (<jats:styled-content style=\"fixed-case\">HDR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ICBT<\/jats:styled-content>) was delivered at either 4 fractions of 6\u00a0Gy or 6 fractions of 4.5\u00a0Gy. The effects of the overall treatment time (<jats:styled-content style=\"fixed-case\">OTT<\/jats:styled-content>) and interval between <jats:styled-content style=\"fixed-case\">EBRT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HDR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ICBT<\/jats:styled-content> on the cancer\u2010specific survival (<jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>), local recurrence (<jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>), and incidence of proctitis were compared. The treatment time\u2010related factors did not adversely affect the <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content> rates. The multivariate analyses did not identify the <jats:styled-content style=\"fixed-case\">OTT<\/jats:styled-content> as an independent factor of <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.839) and <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.856). However, <jats:styled-content style=\"fixed-case\">OTT<\/jats:styled-content> \u226456\u00a0days (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.026) was identified as the only independent factor of overall proctitis. The 5\u2010year Grade 2 or greater proctitis rates were 14.9% and 0% (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001) in patients with the <jats:styled-content style=\"fixed-case\">EBRT<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">ICBT<\/jats:styled-content> interval \u22645\u00a0days and &gt;5\u00a0days, respectively. To reduce rectal damage without compromising prognosis, the gap between <jats:styled-content style=\"fixed-case\">EBRT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HDR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ICBT<\/jats:styled-content> should exceed 5\u00a0days in cervical cancer patients undergoing <jats:styled-content style=\"fixed-case\">CCRT<\/jats:styled-content>. Strictly limiting the <jats:styled-content style=\"fixed-case\">OTT<\/jats:styled-content> to 56\u00a0days may result in radiation proctitis without improvements in prognosis.<\/jats:p>","DOI":"10.1002\/cam4.794","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T06:54:33Z","timestamp":1468565673000},"page":"2205-2212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of treatment time\u2010related factors on prognoses and radiation proctitis after definitive chemoradiotherapy for cervical cancer"],"prefix":"10.1002","volume":"5","author":[{"given":"Eng\u2010Yen","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine  Kaohsiung Taiwan"},{"name":"School of Traditional Chinese Medicine Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong\u2010Jong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan\u2010Chao","family":"Chanchien","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Che","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00439-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(92)90247-R"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90522-W"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90058-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00220-S"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00635-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860410018511"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27652"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.01.037"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00264-Y"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4368"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00560-9"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.03.045"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00766-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14361-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.08.038"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.024"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00539-3"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)89484-9"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00012-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904153401503"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904153401501"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.8.1606"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904153401502"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.5.1339"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-004-0443-z"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.00.0497"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.12.027"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.11.045"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03038241"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181e6f321"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.04.036"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20734"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00288-8"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.794","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.794","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.794","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T02:39:15Z","timestamp":1696559955000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,15]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1002\/cam4.794"],"URL":"https:\/\/doi.org\/10.1002\/cam4.794","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,15]]},"assertion":[{"value":"2016-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}