{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:58:34Z","timestamp":1783547914016,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T00:00:00Z","timestamp":1467072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tokyo Metropolitan Government","award":["H260301002"],"award-info":[{"award-number":["H260301002"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the prognostic significance of sarcopenia in upper tract urothelial carcinoma (<jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>) patients treated with radical nephroureterectomy (<jats:styled-content style=\"fixed-case\">RNU<\/jats:styled-content>). The skeletal muscle index (<jats:styled-content style=\"fixed-case\">SMI<\/jats:styled-content>) was calculated from computed tomography images. Sarcopenia was defined as <jats:styled-content style=\"fixed-case\">SMI<\/jats:styled-content> &lt;43\u00a0cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup> for males with body mass index &lt;25\u00a0kg\/m<jats:sup>2<\/jats:sup>, &lt;53\u00a0cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup> for males with BMI \u226525\u00a0kg\/m<jats:sup>2<\/jats:sup>, and &lt;41\u00a0cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup> for females. Associations of sarcopenia with cancer\u2010specific survival (<jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>) and overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) were evaluated in 81 consecutive <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content> patients who underwent <jats:styled-content style=\"fixed-case\">RNU<\/jats:styled-content>. Forty\u2010seven (58%) out of 81 patients had sarcopenia. Multivariate analyses identified sarcopenia as a significant and independent poor prognostic factor for both <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> (hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>] 8.58, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 1.63\u2013158.1, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.008) and <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 6.05, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.00\u201326.21, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). In patients with locally advanced disease (<jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>3\/4 or <jats:styled-content style=\"fixed-case\">pN<\/jats:styled-content>+), those with sarcopenia showed significantly worse <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> than those without (5\u2010year <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> rate 55% vs. 100%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.014; 5\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> rate 40% vs. 86%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.007). In contrast, no prognostic difference was observed between patients with and without sarcopenia in those with organ\u2010confined disease (<jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>a\u20102pN0\/x). Sarcopenia is an independent poor prognostic factor for <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content> patients treated with <jats:styled-content style=\"fixed-case\">RNU<\/jats:styled-content>, particularly for those with locally advanced disease.<\/jats:p>","DOI":"10.1002\/cam4.795","type":"journal-article","created":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T12:46:02Z","timestamp":1467117962000},"page":"2213-2220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Prognostic significance of sarcopenia in upper tract urothelial carcinoma patients treated with radical nephroureterectomy"],"prefix":"10.1002","volume":"5","author":[{"given":"Hiroshi","family":"Fukushima","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital  3\u201018\u201022 Honkomagome Bunkyo\u2010ku Tokyo 113\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasukazu","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital  3\u201018\u201022 Honkomagome Bunkyo\u2010ku Tokyo 113\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madoka","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital  3\u201018\u201022 Honkomagome Bunkyo\u2010ku Tokyo 113\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010ichi","family":"Tobisu","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital  3\u201018\u201022 Honkomagome Bunkyo\u2010ku Tokyo 113\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitaka","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital  3\u201018\u201022 Honkomagome Bunkyo\u2010ku Tokyo 113\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09675.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.01.021"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.10.057"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2011.96"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.08.019"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2722"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70153-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.08.071"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115895"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.08.072"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28798"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.urolonc.2015.01.011","article-title":"Sarcopenia as a predictor of overall survival after cytoreductive nephrectomy for metastatic renal cell carcinoma","volume":"33","author":"Sharma P.","year":"2015","journal-title":"Urol Oncol."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2009.02366.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","article-title":"Consultation.: appropriate body\u2010mass index for Asian populations and its implications for policy and intervention strategies","volume":"363","author":"Expert W. 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