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A retrospective analysis of contemporary data (2003\u20132011) was performed to provide objective information regarding surgical morbidity, mortality, and survival for patients undergoing <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content> at a comprehensive cancer center. While procedure\u2010associated morbidity was comparable to other major surgical oncology procedures, there was no operative or 30\u2010day mortality and 60\u2010day mortality was 2.7%. Increasing numbers of bowel resections were found to correlate to an increased incidence of deep surgical site infections (including abscess and enterocutaneous fistula) and need for reoperation which was in turn associated with a decreased overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) and progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>). Five\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> rates varied by site of tumor origin and histology (disseminated peritoneal adenomucinosis [91.3%], Mesothelioma [80.8%], Appendiceal Adenocarcinoma [38.7%], and Colorectal Adenocarcinoma [38.2%]). With an acceptable morbidity and mortality rate, <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content> should be included as an effective treatment modality in the multidisciplinary care of select patients with peritoneal metastases.<\/jats:p>","DOI":"10.1002\/cam4.80","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T10:38:44Z","timestamp":1366108724000},"page":"334-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["A contemporary analysis of morbidity and outcomes in cytoreduction\/hyperthermic intraperitoneal chemoperfusion"],"prefix":"10.1002","volume":"2","author":[{"given":"Michelle","family":"Haslinger","sequence":"first","affiliation":[{"name":"Department of Surgery University of Buffalo Buffalo New York"},{"name":"Department of Surgical Oncology Roswell Park Cancer Institute Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Francescutti","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Roswell Park Cancer Institute Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher","family":"Attwood","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Roswell Park Cancer Institute Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith Andrea","family":"McCart","sequence":"additional","affiliation":[{"name":"Department of Surgery Mount Sinai Hospital and the University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan","family":"Fakih","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"John M.","family":"Kane","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Roswell Park Cancer Institute Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Skitzki","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Roswell Park Cancer Institute Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890115)63:2<364::AID-CNCR2820630228>3.0.CO;2-V"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000115)88:2<358::AID-CNCR16>3.0.CO;2-O"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.07.113"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11\u20109\u2010981"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.7147"},{"key":"e_1_2_7_7_1","volume-title":"Tumors of the female pelvic organs","author":"Meigs J.","year":"1934"},{"key":"e_1_2_7_8_1","first-page":"235","article-title":"Role of cytoreductive surgical treatment in the management of advanced ovarian cancer","volume":"63","author":"Griffiths C. 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