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Early detection is necessary to prevent the high mortality rate associated with heart failure (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>). We evaluated cardiac function in 142 patients using conventional echocardiography and the phased tracking method (<jats:styled-content style=\"fixed-case\">PTM<\/jats:styled-content>), which was measured using the minute vibration and the rapid motion components, neither of which is recognized in standard M\u2010mode nor in tissue Doppler imaging. For systolic function comparison, we compared left ventricular ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>) in conventional echocardiography with the average velocity of ventricular septum myocytes (V<jats:sub>ave<\/jats:sub>) in the <jats:styled-content style=\"fixed-case\">PTM<\/jats:styled-content>. The V<jats:sub>ave<\/jats:sub> of 12 healthy volunteers was 1.5 (m\/s)\/m or more. At baseline of 99 patients, there was a positive correlation between <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> and V<jats:sub>ave<\/jats:sub> in all patients. There were no significant differences in baseline cardiac function between patients with and without <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>. There was a negative correlation between the cumulative anthracycline dose and <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> or V<jats:sub>ave<\/jats:sub> among all patients. We determined that V<jats:sub>ave<\/jats:sub> 1.5 (m\/s)\/m was equivalent to <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> 60%, 1.25 (m\/s)\/m to 55%, and 1.0 (m\/s)\/m to 50%. During the follow\u2010up period, there was a pathological decrease in <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> (&lt;55%) and V<jats:sub>ave<\/jats:sub> (&lt;1.25\u00a0m\/s\/m) in patients with <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>; decreases in V<jats:sub>ave<\/jats:sub> were detected significantly earlier than those in <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). When V<jats:sub>ave<\/jats:sub> declined to 1.5 (m\/s)\/m or less, careful continuous observation and cardiac examination was required. When V<jats:sub>ave<\/jats:sub> further declined to 1.0 (m\/s)\/m or lower, chemotherapy was postponed or discontinued; thus, serious drug\u2010induced cardiomyopathy was avoided in patients who did not relapse. The <jats:styled-content style=\"fixed-case\">PTM<\/jats:styled-content> was superior to echocardiography for early, noninvasive detection and intermediate\u2010term monitoring of left ventricle systolic function associated with anthracycline chemotherapy, among patients with hematologic malignancies. The <jats:styled-content style=\"fixed-case\">PTM<\/jats:styled-content> was an effective laboratory procedure to avoid the progression to serious cardiomyopathy.<\/jats:p>","DOI":"10.1002\/cam4.813","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T10:58:01Z","timestamp":1470221881000},"page":"2276-2285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Noninvasive early detection of anthracycline\u2010induced cardiotoxicity in patients with hematologic malignancies using the phased tracking method"],"prefix":"10.1002","volume":"5","author":[{"given":"Yoshiko","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition Miyagigakuin Women's University  Sendai Japan"},{"name":"Sendai Blood Disease Center  Sendai 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