{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T05:15:02Z","timestamp":1723094102123},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T00:00:00Z","timestamp":1469577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004602","name":"Program for New Century Excellent Talents in University","doi-asserted-by":"publisher","award":["NCET\u201012\u20100209"],"award-info":[{"award-number":["NCET\u201012\u20100209"]}],"id":[{"id":"10.13039\/501100004602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003181","name":"Foundation for the Author of National Excellent Doctoral Dissertation of the People's Republic of China","doi-asserted-by":"publisher","award":["201484"],"award-info":[{"award-number":["201484"]}],"id":[{"id":"10.13039\/501100003181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Abstract<\/jats:title>It was reported that DNA<\/jats:styled-content> repair can confer cancer cell resistance to therapeutic treatments by activating antiapoptotic cellular defense. We hypothesized that genetic variants of DNA<\/jats:styled-content> repair genes may be associated with lung cancer prognosis. Seventeen tagging single\u2010nucleotide polymorphism (tagSNP<\/jats:styled-content>s) selected from 12 DNA<\/jats:styled-content> repair genes were genotyped in 280 advanced non\u2010small\u2010cell lung cancer (NSCLC<\/jats:styled-content>) patients by TaqMan assay. The associations of these SNP<\/jats:styled-content>s and overall survival of advanced NSCLC<\/jats:styled-content> patients were investigated. Advanced NSCLC<\/jats:styled-content> patients carrying ERCC<\/jats:styled-content>2<\/jats:italic> rs50872 CT<\/jats:styled-content>+TT<\/jats:styled-content> genotypes had significantly longer median survival time (MST<\/jats:styled-content>) and decreased death risk than patients with rs50872 CC<\/jats:styled-content> genotype [log\u2010rank P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.031; adjusted HR<\/jats:styled-content>(95% CI<\/jats:styled-content>)\u00a0=\u00a00.73 (0.55\u20130.98), P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.033]. These effects were mainly seen among younger patients (\u226465\u00a0years old) [HR<\/jats:styled-content>(95% CI<\/jats:styled-content>)\u00a0=\u00a00.57 (0.37\u20130.87), P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.010], patients without surgery [HR<\/jats:styled-content>(95% CI<\/jats:styled-content>)\u00a0=\u00a00.68 (0.47\u20130.98), P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.036] but with chemotherapy [HR<\/jats:styled-content>(95% CI<\/jats:styled-content>)\u00a0=\u00a00.64 (0.46\u20130.91), P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.012] or radiotherapy [HR<\/jats:styled-content>(95% CI<\/jats:styled-content>)\u00a0=\u00a00.58 (0.38\u20130.89), P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.013]. Meanwhile, compared to advanced NSCLC<\/jats:styled-content> patients with rs25487 GG<\/jats:styled-content> genotype, patients carrying XRCC<\/jats:styled-content>1<\/jats:italic> rs25487 GA<\/jats:styled-content>+AA<\/jats:styled-content> genotypes had significantly shorter MST<\/jats:styled-content> (MST<\/jats:styled-content>\u00a0=\u00a011.7 vs. 16.7, log\u2010rank P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.048). In addition, advanced NSCLC<\/jats:styled-content> patients carrying the ERCC<\/jats:styled-content>2<\/jats:italic> rs50872 CC<\/jats:styled-content> in combination with XRCC<\/jats:styled-content>1<\/jats:italic> rs25487 GA<\/jats:styled-content>+AA<\/jats:styled-content> genotype had the shortest MST<\/jats:styled-content> (11.2\u00a0month) and highest death risk [HR<\/jats:styled-content>(95% CI<\/jats:styled-content>)\u00a0=\u00a01.70 (1.15\u20132.52), P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.008] when compared with those carrying rs50872 CT<\/jats:styled-content>+TT<\/jats:styled-content> and rs25487 GG<\/jats:styled-content> genotype (MST<\/jats:styled-content>\u00a0=\u00a022.0\u00a0month). The ERCC<\/jats:styled-content>2<\/jats:italic> rs50872 T allele was associated with favorable but XRCC<\/jats:styled-content>1<\/jats:italic> rs25487 A allele with bad survival for advanced NSCLC<\/jats:styled-content> in Chinese population, which may offer novel biomarkers for predicting clinical outcomes.<\/jats:p>","DOI":"10.1002\/cam4.822","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T01:14:35Z","timestamp":1469668475000},"page":"2332-2342","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The genetic variations in DNA repair genes ERCC2<\/i> and XRCC1<\/i> were associated with the overall survival of advanced non\u2010small\u2010cell lung cancer patients"],"prefix":"10.1002","volume":"5","author":[{"given":"Suhan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology Wuhan Iron and Steel (Group) Corporation Staff\u2010Worker Hospital Wuhan 430085 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yansen","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology Wuhan Iron and Steel (Group) Corporation Staff\u2010Worker Hospital Wuhan 430085 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