{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T08:04:47Z","timestamp":1758873887291},"reference-count":76,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,21]],"date-time":"2013-04-21T00:00:00Z","timestamp":1366502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effectiveness of screening programs for cervical cancer has benefited from the inclusion of Human papillomavirus (HPV) DNA assays; which assay to choose, however, is not clear based on previous reviews. Our review addressed test accuracy of Hybrid Capture II (HCII) and polymerase chain reaction (PCR) assays based on studies with stronger designs and with more clinically relevant outcomes. We searched OvidMedline, PubMed, and the Cochrane Library for English language studies comparing both tests, published 1985\u20132012, with cervical dysplasia defined by the Bethesda classification. Meta\u2010analysis provided pooled sensitivity, specificity, and 95% confidence intervals (CIs); meta\u2010regression identified sources of heterogeneity. From 29 reports, we found that the pooled sensitivity and specificity to detect high\u2010grade squamous intraepithelial lesion (HSIL) was higher for HCII than PCR (0.89 [CI: 0.89\u20130.90] and 0.85 [CI: 0.84\u20130.86] vs. 0.73 [CI: 0.73\u20130.74] and 0.62 [CI: 0.62\u20130.64]). Both assays had higher accuracy to detect cervical dysplasia in Europe than in Asia\u2010Pacific or North America (diagnostic odd ratio \u2013 dOR\u00a0=\u00a04.08 [CI: 1.39\u201311.91] and 4.56 [CI: 1.86\u201311.17] for HCII vs. 2.66 [CI: 1.16\u20136.53] and 3.78 [CI: 1.50\u20139.51] for PCR) and accuracy to detect HSIL than atypical squamous cells of undetermined significance (ASCUS)\/ low\u2010grade squamous intraepithelial lesion (LSIL) (HCII\u2010<jats:styled-content style=\"fixed-case\">dOR<\/jats:styled-content>\u00a0=\u00a09.04 [CI: 4.12\u201319.86] and PCR\u2010<jats:styled-content style=\"fixed-case\">dOR<\/jats:styled-content>\u00a0=\u00a05.60 [CI: 2.87\u201310.94]). For HCII, using histology as a gold standard results in higher accuracy than using cytology (<jats:styled-content style=\"fixed-case\">dOR<\/jats:styled-content>\u00a0=\u00a02.87 [CI: 1.31\u20136.29]). Based on higher test accuracy, our results support the use of HCII in cervical cancer screening programs. The role of HPV type distribution should be explored to determine the worldwide comparability of HPV test accuracy.<\/jats:p>","DOI":"10.1002\/cam4.83","type":"journal-article","created":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T03:46:37Z","timestamp":1366602397000},"page":"367-390","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of the accuracy of Hybrid Capture II and polymerase chain reaction in detecting clinically important cervical dysplasia: a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"2","author":[{"given":"Hung N.","family":"Luu","sequence":"first","affiliation":[{"name":"Dan L. Duncan Cancer Center Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina R.","family":"Dahlstrom","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Human Genetics and Environmental Sciences School of Public Health University of Texas Health Science Center\u2010Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Dolan","family":"Mullen","sequence":"additional","affiliation":[{"name":"Division of Health Promotion and Behavioral Sciences School of Public Health University of Texas Health Science Center\u2010Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena M.","family":"VonVille","sequence":"additional","affiliation":[{"name":"Library Director School of Public Health University of Texas Health Science Center\u2010Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Scheurer","sequence":"additional","affiliation":[{"name":"Dan L. Duncan Cancer Center Baylor College of Medicine Houston Texas"},{"name":"Department of Pediatrics Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.4.244"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7193.1244"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602541"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1002\/ijc.23276","article-title":"Mass screening programmes and trends in cervical cancer in Finland and the Netherlands","volume":"122","author":"Aa M. A.","year":"2008","journal-title":"Int. J. Cancer"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.117"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.08.053"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh037"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22751"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.01.008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1057"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.1.46"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23339"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.581"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26056"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.07.033"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.10.104"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24010"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1309\/RNF3C01JKADQCLKP"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21801"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-1-200301070-00010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199909000-00009"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02438-06"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2307\/3001666"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470712184.ch9"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-6-31"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0508"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1185"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19991030)18:20<2693::AID-SIM235>3.0.CO;2-V"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00177-X"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)00795-X"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(02)00007-0"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.9.4022-4030.2003"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326549"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.6.2470-2475.2004"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326413"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.lgt.0000179861.67574.6b"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1309\/E067X0L1U3CY37NW"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.7.3260-3266.2005"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.5.1733-1739.2006"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00706-06"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02098-06"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00992-06"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340601033667"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2007.07.023"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21191"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.09.012"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2009.10.013"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01707-08"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02943.x"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00422-11"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.07.036"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.03.010"},{"key":"e_1_2_7_59_1","first-page":"372","article-title":"Histopathologic extent of cervical intraepithelial neoplasia 3 lesions in the atypical squamous cells of undetermined significance low\u2010grade squamous intraepithelial lesion triage study: implications for subject safety and lead\u2010time bias","volume":"12","author":"Sherman M. E.","year":"2003","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22527"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70360-2"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073204"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70296-0"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071430"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70188-7"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808516"},{"key":"e_1_2_7_67_1","first-page":"340","article-title":"consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ","volume":"2007","author":"Wright T. C.","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_2_7_68_1","first-page":"295","article-title":"consensus guidelines for the management of women with cervical intraepithelial neoplasia","volume":"2003","author":"Wright T. C.","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0812"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.02.003"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg037"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17354-6"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06809-X"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.461"},{"key":"e_1_2_7_75_1","unstructured":"US Preventive Services Task Force.2012.Screening for cervical cancer. Available athttp:\/\/www.uspreventiveservicestaskforce.org\/3rduspstf\/cervcan\/cervcanrr.pdf(accessed 10 October 2012)."},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690730"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.16"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.83","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.83","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.83","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.83","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:06:39Z","timestamp":1698656799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.83"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,21]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1002\/cam4.83"],"URL":"https:\/\/doi.org\/10.1002\/cam4.83","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,21]]},"assertion":[{"value":"2013-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}