{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:27:54Z","timestamp":1769243274052,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007365","name":"Fondazione IRCCS Policlinico San Matteo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Abstract<\/jats:title>Categorization of primary cutaneous B\u2010cell lymphomas (PCBCL<\/jats:styled-content>) other than marginal zone (MZL<\/jats:styled-content>) represents a diagnostic challenge with relevant prognostic implications. The 2008 WHO<\/jats:styled-content> lymphoma classification recognizes only primary cutaneous follicular center cell lymphoma (PCFCCL<\/jats:styled-content>) and primary cutaneous diffuse large B\u2010cell lymphoma, leg type (PCDLBCL<\/jats:styled-content>\u2010LT<\/jats:styled-content>), whereas the previous 2005 WHO<\/jats:styled-content>\/EORTC<\/jats:styled-content> classification also included an intermediate form, namely PCDLBCL<\/jats:styled-content>, other. We conducted a retrospective, multicentric, consensus\u2010based revision of the clinicopathologic characteristics of 161 cases of PCBCL<\/jats:styled-content> other than MZL<\/jats:styled-content>. Upon the histologic features that are listed in the WHO<\/jats:styled-content> classification, 96 cases were classified as PCFCCL<\/jats:styled-content> and 25 as PCDLBCL<\/jats:styled-content>\u2010LT<\/jats:styled-content>; 40 further cases did not fit in the former subgroups in terms of cytology and\/or architecture, thus were classified as PCDLBCL<\/jats:styled-content>, not otherwise specified (PCDLBCL<\/jats:styled-content>\u2010NOS<\/jats:styled-content>). We assigned all the cases a histogenetic profile, based on the immunohistochemical detection of CD<\/jats:styled-content>10, BCL<\/jats:styled-content>6, and MUM<\/jats:styled-content>1, and a \u201cdouble hit score\u201d upon positivity for BCL<\/jats:styled-content>2 and MYC<\/jats:styled-content>. PCDLBCL<\/jats:styled-content>\u2010NOS<\/jats:styled-content> had a clinical presentation more similar to PCFCCL<\/jats:styled-content>, whereas the histology was more consistent with the picture of a diffuse large B\u2010cell lymphoma, as predominantly composed of centroblasts but with intermixed a reactive infiltrate of small lymphocytes. Its behavior was intermediate between the other two forms, particularly when considering only cases with a \u201cnon\u2010germinal B\u2010cell\u201d profile, whereas \u201cgerminal center\u201d cases resembled PCFCCL<\/jats:styled-content>. Our data confirmed the aggressive behavior of PCDLBC<\/jats:styled-content>\u2010LT<\/jats:styled-content>, which often coexpressed MYC<\/jats:styled-content> and BCL<\/jats:styled-content>2. The impact of single factors on 5\u2010year survival was documented, particularly histogenetic profile in PCDLBCL<\/jats:styled-content> and BCL<\/jats:styled-content>2 translocation in PCFCCL<\/jats:styled-content>. Our study confirms that a further group\u2014PCDLBCL<\/jats:styled-content>\u2010NOS<\/jats:styled-content>\u2014exists, which can be recognized through a careful combination of histopathologic criteria coupled with adequate clinical information.<\/jats:p>","DOI":"10.1002\/cam4.865","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T10:23:25Z","timestamp":1474885405000},"page":"2740-2755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Primary cutaneous B\u2010cell lymphoma other than marginal zone: clinicopathologic analysis of 161 cases: Comparison with current classification and definition of prognostic markers"],"prefix":"10.1002","volume":"5","author":[{"given":"Marco","family":"Lucioni","sequence":"first","affiliation":[{"name":"Unit of Anatomic Pathology Department of Molecular Medicine University of Pavia and Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6753-4910","authenticated-orcid":false,"given":"Emilio","family":"Berti","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fondazione IRCCS Ca\u2019 Granda \u2010 Ospedale Maggiore Policlinico and Universit\u00e0 degli Studi di Milano\u2010Bicocca Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Arcaini","sequence":"additional","affiliation":[{"name":"Section of Hematology\u2010Oncology Department of Molecular Medicine University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio A.","family":"Croci","sequence":"additional","affiliation":[{"name":"Unit of Anatomic Pathology Department of Molecular Medicine University of Pavia and Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Maffi","sequence":"additional","affiliation":[{"name":"Unit of Anatomic Pathology Department of Molecular Medicine University of Pavia and Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Klersy","sequence":"additional","affiliation":[{"name":"Scientific Direction Biometry and Statistics Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaia","family":"Goteri","sequence":"additional","affiliation":[{"name":"Pathologic Anatomy and Histopathology Department of Biomedical Sciences and Public Health Polytechnic University of Marche Region United Ancona Hospitals Torrette Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Tomasini","sequence":"additional","affiliation":[{"name":"Pathology Unit Department of Laboratory Medicine Azienda Ospedaliera Citt\u00e0 della Salute e della Scienza di Torino Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Quaglino","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Riboni","sequence":"additional","affiliation":[{"name":"Unit of Anatomic Pathology Department of Molecular Medicine University of Pavia and Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariarosa","family":"Arra","sequence":"additional","affiliation":[{"name":"Unit of Anatomic Pathology Department of Molecular Medicine University of Pavia and Fondazione IRCCS Policlinico San Matteo Pavia 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Zerbinati","sequence":"additional","affiliation":[{"name":"Department of Surgical and Morphological Sciences Faculty of Medicine and Surgery University of Insubria Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2991-3474","authenticated-orcid":false,"given":"Francesco","family":"Onida","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Center Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico and University of Milan Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Ascani","sequence":"additional","affiliation":[{"name":"Institute of Pathology Ospedale S. 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