{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:15:11Z","timestamp":1769764511045,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Capital Medical Development Scientific Research Fund","award":["2016-2-4016"],"award-info":[{"award-number":["2016-2-4016"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the study was to investigate the relationship between PD\u20101 expression on the surface of CD4<jats:sup>+<\/jats:sup> T cells and prognosis of patients with diffuse large B\u2010cell lymphoma (DLBCL). Sixty patients who were newly diagnosed with DLBCL and 39 healthy controls were enrolled. In CD4<jats:sup>+<\/jats:sup> T cells of DLBCL patients, the median MFI of PD\u20101 were 541.5 (range: 348.25\u2013758.75), significantly higher than 250 (range: 211\u2013326) in healthy controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The ZAP70, PI3K, and NFAT mRNA expression levels of patients were 0.47, 0.47, and 0.62 times, respectively, of those of the healthy controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In patients with the percentage of PD\u20101 on CD4<jats:sup>+<\/jats:sup> T cells \u226530.25%, their EFS and OS were significantly lower than patients with PD\u20101<jats:sup>+<\/jats:sup> CD4<jats:sup>+<\/jats:sup> T cells &lt;30.25% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The possible explanation is that high PD\u20101 expression on CD4<jats:sup>+<\/jats:sup> cells of DLBCL patients may impair T\u2010cell function and thus contribute to poor prognosis. There was no relationship between PD\u20101 surface expression on CD4<jats:sup>+<\/jats:sup> T cells and PD\u20101 expression within the biopsy of tumor microenvironments from DLBCL patients.<\/jats:p>","DOI":"10.1002\/cam4.874","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T21:07:09Z","timestamp":1476306429000},"page":"3077-3084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["PD\u20101 expression on the surface of peripheral blood CD4<sup>+<\/sup> T cell and its association with the prognosis of patients with diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"5","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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