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We previously showed that obese postmenopausal women with estrogen receptor (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>)\u2010negative breast cancer have a fivefold higher risk of <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content> compared with normal weight women. In the current analysis, we reexamined this relationship in the expanded Women's Environmental Cancer and Radiation Epidemiology (<jats:styled-content style=\"fixed-case\">WECARE<\/jats:styled-content>) Study, focusing on the impact of menopausal status and <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> status of the first breast cancer. The <jats:styled-content style=\"fixed-case\">WECARE<\/jats:styled-content> Study is a population\u2010based case\u2013control study of young women with <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content> (cases, <jats:italic>N<\/jats:italic>\u00a0=\u00a01386) and with unilateral breast cancer (controls, <jats:italic>N<\/jats:italic>\u00a0=\u00a02045). Rate ratios (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) were calculated to assess the relationship between <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and risk of <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content> stratified by menopausal and <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> status. Positive associations with obesity and weight gain were limited to women who became postmenopausal following their first primary breast cancer. Among those with an <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010negative first breast cancer, obesity (vs. normal weight) at first diagnosis was associated with an increased risk of <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u00a0=\u00a01.9, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.02, 3.4). Also, weight gain of \u226510\u00a0kg after first diagnosis was associated with an almost twofold increased risk of <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u00a0=\u00a01.9, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.99, 3.8). These results suggest that women with an <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010negative first primary cancer who are obese at first primary diagnosis or who experience a large weight gain afterward may benefit from heightened surveillance. Future studies are needed to address the impact of weight loss interventions on risk of <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/cam4.890","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T16:05:52Z","timestamp":1476201952000},"page":"3282-3291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Body mass index, weight change, and risk of second primary breast cancer in the <scp>WECARE<\/scp> study: influence of estrogen receptor status of the first breast cancer"],"prefix":"10.1002","volume":"5","author":[{"given":"Jennifer D.","family":"Brooks","sequence":"first","affiliation":[{"name":"University of Toronto Dalla Lana School of Public Health Sciences  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther M.","family":"John","sequence":"additional","affiliation":[{"name":"Cancer Prevention Institute of California  Fremont California"},{"name":"Department of Health Research and Policy (Epidemiology) Stanford University School of Medicine  Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene","family":"Mellemkj\u00e6r","sequence":"additional","affiliation":[{"name":"Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles F.","family":"Lynch","sequence":"additional","affiliation":[{"name":"University of Iowa  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia A.","family":"Knight","sequence":"additional","affiliation":[{"name":"University of Toronto Dalla Lana School of Public Health Sciences  Toronto Canada"},{"name":"Lunenfeld\u2010Tanenbaum Research Institute Mount Sinai Hospital  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen E.","family":"Malone","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne S.","family":"Reiner","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Beckman Research Institute City of Hope National Medical Center  Duarte California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Liang","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy E.","family":"Shore","sequence":"additional","affiliation":[{"name":"Department of Population Health New York University School of Medicine  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Stovall","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"WECARE Study Collaborative Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonine L.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,3]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Food, nutrition, physcial activity, and the prevention of cancer research","author":"World Cancer Research Fund\/American Institute for Cancer Research","year":"2007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20315"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9292-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020239211145"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg022"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-008-0069-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(88)90173-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1109"},{"key":"e_1_2_7_10_1","volume-title":"Chapter 7: new malignancies following breast cancer","author":"Curtis R. 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