{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:48:43Z","timestamp":1777110523540,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Materion Brush Inc"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed at investigating mortality among beryllium\u2010exposed workers, according to solubility of beryllium and beryllium compounds. We conducted an historical cohort study of 16,115 workers employed during 1925\u20132008 in 15 facilities, including eight entailing exposure to insoluble beryllium and seven entailing exposure to soluble\/mixed beryllium compounds, who were followed up for mortality until 2011. Data were analyzed using indirect standardization and Cox regression modeling. Lung cancer standardized mortality ratio (<jats:styled-content style=\"fixed-case\">SMR<\/jats:styled-content>, national reference rates) was 1.02 (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 0.94\u20131.10) in the whole cohort, 0.88 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.75\u20131.03) in the insoluble beryllium subcohort, and 1.09 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.99\u20131.09) in the soluble\/mixed beryllium subcohort. For lung cancer, there was an association with period of hire in soluble\/mixed beryllium plants but not in insoluble plants, and, conversely, employment in soluble\/mixed plants was associated with increased mortality only among workers hired before 1955. There was no trend with duration of employment. Mortality from chronic beryllium disease increased, in particular, among workers hired before 1955 in soluble\/mixed beryllium facilities. There was no increase in lung cancer mortality in the entire cohort and lung cancer mortality was not increased among beryllium workers hired in 1955 or later in soluble\/mixed beryllium facilities, or at any time among those employed in insoluble beryllium facilities.<\/jats:p>","DOI":"10.1002\/cam4.918","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T04:06:48Z","timestamp":1477022808000},"page":"3596-3605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A mortality study of beryllium workers"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-2791","authenticated-orcid":false,"given":"Paolo","family":"Boffetta","sequence":"first","affiliation":[{"name":"Tisch Cancer Institute Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffani A.","family":"Fordyce","sequence":"additional","affiliation":[{"name":"Exponent Inc.  Oakland California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack S.","family":"Mandel","sequence":"additional","affiliation":[{"name":"Exponent Inc.  Oakland California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(80)90007-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(80)90004-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700220610"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0274(200102)39:2<133::AID-AJIM1001>3.0.CO;2-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0274(200102)39:2<145::AID-AJIM1002>3.0.CO;2-Y"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2010.056481"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2010.056515"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/meq071"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/meq073"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113645"},{"key":"e_1_2_7_13_1","volume-title":"Statistical Methods in Cancer Research. 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