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We examined five single\u2010nucleotide polymorphisms (\n SNP<\/jats:styled-content>\n s) in three\n \n ATG<\/jats:styled-content>\n <\/jats:italic>\n genes (\n \n ATG<\/jats:styled-content>\n 5\n <\/jats:italic>\n ;\n \n ATG<\/jats:styled-content>\n 10\n <\/jats:italic>\n ; and\n \n ATG<\/jats:styled-content>\n 16L\n <\/jats:italic>\n ) with known or suspected impact on autophagic flux in an international population\u2010based case\u2013control study of melanoma.\n DNA<\/jats:styled-content>\n from 911 melanoma patients was genotyped. An association was identified between (\n GG<\/jats:styled-content>\n ) (rs2241880) and earlier stage at diagnosis (\n OR<\/jats:styled-content>\n 0.47; 95% Confidence Intervals (\n CI<\/jats:styled-content>\n )\u00a0=\u00a00.27\u20130.81,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.02) and a decrease in Breslow thickness (\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.03). The\n \n ATG<\/jats:styled-content>\n 16L\n <\/jats:italic>\n heterozygous genotype (\n AG<\/jats:styled-content>\n ) (rs2241880) was associated with younger age at diagnosis (\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.02). Two\n SNP<\/jats:styled-content>\n s in\n \n ATG<\/jats:styled-content>\n 5\n <\/jats:italic>\n were found to be associated with increased stage (rs2245214\n CG<\/jats:styled-content>\n ,\n OR<\/jats:styled-content>\n 1.47; 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.11\u20131.94,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.03; rs510432\n CC<\/jats:styled-content>\n ,\n OR<\/jats:styled-content>\n 1.84; 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.12\u20133.02,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.05). Finally, we identified inverse associations between\n \n ATG<\/jats:styled-content>\n 5\n <\/jats:italic>\n (\n GG<\/jats:styled-content>\n rs2245214) and melanomas on the scalp or neck (\n OR<\/jats:styled-content>\n 0.20, 95%\n CI<\/jats:styled-content>\n = 0.05\u20130.86,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.03);\n \n ATG<\/jats:styled-content>\n 10\n <\/jats:italic>\n (\n CC<\/jats:styled-content>\n ) (rs1864182) and brisk tumor infiltrating lymphocytes (\n TIL<\/jats:styled-content>\n s) (\n OR<\/jats:styled-content>\n 0.42; 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.21\u20130.88,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.02), and\n \n ATG<\/jats:styled-content>\n 5\n <\/jats:italic>\n (\n CC<\/jats:styled-content>\n ) (rs510432) with nonbrisk\n TIL<\/jats:styled-content>\n s (\n OR<\/jats:styled-content>\n 0.55; 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.34\u20130.87,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.01). Our data suggest that\n \n ATG<\/jats:styled-content>\n <\/jats:italic>\n SNP<\/jats:styled-content>\n s might be differentially associated with specific host and tumor characteristics including age at diagnosis,\n TIL<\/jats:styled-content>\n s, and stage. These associations may be critical to understanding the role of autophagy in cancer, and further investigation will help characterize the contribution of these variants to melanoma progression.\n <\/jats:p>","DOI":"10.1002\/cam4.929","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T04:16:52Z","timestamp":1476677812000},"page":"3336-3345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Variants in autophagy\u2010related genes and clinical characteristics in melanoma: a population\u2010based study"],"prefix":"10.1002","volume":"5","author":[{"given":"Kirsten A. 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