{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:14:30Z","timestamp":1787318070758,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T00:00:00Z","timestamp":1538092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2019,3]]},"abstract":"\n Introduction<\/jats:title>\n Localized aggressive periodontal disease is an uncommon finding observed in adolescents and children. Studies have been conducted to elucidate the etiology, contributing factors, and genetic roles in the phenomena. In particular, twin studies have shown genetic makeup to be a substantial risk factor for periodontitis. This case is, to the best of the authors\u2019 knowledge, the first to be presented in literature of a same dwelling, set of monozygotic twins, displaying similar presentation of localized aggressive periodontitis, however with different microbial profiles.<\/jats:p>\n <\/jats:sec>\n \n Case Presentation<\/jats:title>\n A set of 17\u2010year\u2010old black male monozygotic twins were referred for a full\u2010mouth periodontal evaluation and any necessary periodontal treatment on July 7, 2007. A full\u2010mouth radiographic series, periodontal charting, and intraoral photographs were performed on each individual. A family history was obtained through the biological mother, which yielded no known history of early tooth loss or treatment of severe periodontal disease. The father was not involved in the rearing of the children and his periodontal history was unavailable. An initial and surgical treatment plan was developed. Microbial analysis of subgingival plaque samples was collected on the affected sites. Initial treatment with scaling and root planing, subgingival irrigation, with administration of systemic antibiotics, and oral hygiene instruction, were rendered on both individuals.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Within limitations of this report, it is demonstrated that different microbial pattern exists on aggressive periodontitis even in genetically identical individuals with the same environmental exposure.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cap.10041","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T12:23:00Z","timestamp":1535977380000},"page":"9-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Presentation of Localized Aggressive Periodontitis in Monozygotic Twins: Case Report"],"prefix":"10.1002","volume":"9","author":[{"given":"Sharon","family":"Phamduong","sequence":"first","affiliation":[{"name":"Private practice Sunnyvale CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Periodontics Western University of Health Sciences, College of Dental Medicine Pomona CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,28]]},"reference":[{"key":"e_1_2_9_2_1","article-title":"Consensus report: aggressive periodontitis","author":"Lang N","year":"1999","journal-title":"Ann Periodontol"},{"key":"e_1_2_9_3_1","first-page":"7","article-title":"Seymour, Comparative biology of chronic and aggressive periodontitis: introduction","volume":"2010","author":"Armitage G","year":"2000","journal-title":"Periodontol"},{"key":"e_1_2_9_4_1","unstructured":"Retrieved fromhttps:\/\/dentists.usc.edu\/files\/2015\/02\/Website-Kit-Instructions.pdf"},{"key":"e_1_2_9_5_1","unstructured":"J Periodontol 2004 Position paper: systemic antibiotics in periodontics"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1034\/j.1600-0765.2003.02016.x","article-title":"Povidone\u2010iodine as a periodontal pocket disinfectant","author":"Hoang T","year":"2003","journal-title":"J Periodontal Res"},{"key":"e_1_2_9_7_1","first-page":"79","article-title":"Finding genetic risk factors for periodontal diseases: is the climb worth the view","volume":"2002","author":"Schenkein HA.","year":"2000","journal-title":"Periodontol"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374930070020701"},{"key":"e_1_2_9_9_1","first-page":"20","article-title":"Composition and development of oral bacterial communities","volume":"2014","author":"Palmer RJ","year":"2000","journal-title":"Periodontol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1128\/JB.00542-10","article-title":"The human oral microbiome","author":"Dewhirst FE","year":"2010","journal-title":"J Bacteriol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1902\/jop.2005.76.2.289","article-title":"Prevalence of periodontopathic bacteria in aggressive periodontitis patients in a Chilean population","author":"Gajardo M","year":"2005","journal-title":"J Periodontol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1902\/jop.2005.76.9.1567","article-title":"Tetraploid\/diploid mosaicism with generalized aggressive periodontitis","author":"T\u00f6z\u00fcm TF","year":"2005","journal-title":"J Periodontol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.tig.2015.03.013","article-title":"Somatic mosaicism: implications for disease and transmission genetics.","author":"Campbell IM","year":"2015","journal-title":"Trends Genet"},{"key":"e_1_2_9_14_1","first-page":"28","article-title":"Periodontal herpesviruses: prevalence, pathogenicity, systemic risk","volume":"2015","author":"Slots J","year":"2000","journal-title":"Periodontol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-017-0385-8"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/BF03262831","article-title":"Case report: identical twins revealing discordant hypodontia. The rationale of dental arch differences in monozygotic twins","author":"Varela M","year":"2011","journal-title":"Eur Arch Paediatr Dent"}],"container-title":["Clinical Advances in Periodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcap.10041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cap.10041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:34:16Z","timestamp":1760045656000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/cap.10041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,28]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/cap.10041"],"URL":"https:\/\/doi.org\/10.1002\/cap.10041","archive":["Portico"],"relation":{},"ISSN":["2573-8046","2163-0097"],"issn-type":[{"value":"2573-8046","type":"print"},{"value":"2163-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,28]]},"assertion":[{"value":"2018-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}