{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:53:29Z","timestamp":1760061209203,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T00:00:00Z","timestamp":1538092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The peripheral ossifying fibroma (POF) is a benign reactive lesion that exclusively arises from gingiva. The lesion may gain considerably large sizes and present peculiar clinical and radiographic features that would then allow it to be called a giant POF; in that case, its otherwise simple surgical extraction could create a challenge. Thus, we elect here, for the very first time, a plausible alternative for treating giant POF: piezosurgery followed by placement of platelet\u2010rich fibrin (PRF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 31\u2010year\u2010old black male presented a large asymptomatic nodule on the lower gingiva; the lesion had caused vestibular displacement of teeth and had been present for 18 years. Following the diagnostic hypothesis of a giant POF, an excisional biopsy was performed under local anesthesia using piezosurgery (microvibration of 36,000 times\/sec was used in a bone cortical working mode), which confirmed the diagnosis. The surgical procedure was facilitated with the use of piezosurgery followed by placement of PRF, being the trans\u2010 and postoperative periods occurred with no complications. One year after the treatment, the patient shows no signs of disease recurrence and remains under follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Giant POF is a rare gingival reactive lesion that can reach large dimensions, causing teeth displacement, functional, and esthetic impairments. The lesion can be successfully managed with piezosurgery and PRF, as illustrated herein, avoiding extensive bone loss and damage to the surrounding soft tissues.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cap.10042","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T12:34:54Z","timestamp":1536150894000},"page":"15-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Giant Peripheral Ossifying Fibroma Treated With Piezosurgery and Platelet\u2010Rich Fibrin: A Rare Case Report"],"prefix":"10.1002","volume":"9","author":[{"given":"Alice E.N.","family":"Freire","sequence":"first","affiliation":[{"name":"Department of Clinic and Surgery School of Dentistry Federal University of Alfenas  Alfenas MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa S.A.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Clinic and Surgery School of Dentistry Federal University of Alfenas  Alfenas MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro A.C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Pathology and Parasitology Institute of Biomedical Sciences Federal University of Alfenas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9 V.","family":"Ribeiro Junior","sequence":"additional","affiliation":[{"name":"Department of Clinic and Surgery School of Dentistry Federal University of Alfenas  Alfenas MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina L.","family":"de Carli","sequence":"additional","affiliation":[{"name":"Department of Clinic and Surgery School of Dentistry Federal University of Alfenas  Alfenas MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe F.","family":"Sperandio","sequence":"additional","affiliation":[{"name":"Department of Pathology and Parasitology Institute of Biomedical Sciences Federal University of Alfenas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Adolfo C.","family":"Hanemann","sequence":"additional","affiliation":[{"name":"Department of Clinic and Surgery School of Dentistry Federal University of Alfenas  Alfenas MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00895.x"},{"key":"e_1_2_10_3_1","first-page":"190592","article-title":"Peripheral ossifying fibroma in the oral cavity: MRI findings","volume":"2011","author":"Chaudhari S","year":"2011","journal-title":"Case Rep 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