{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T22:11:28Z","timestamp":1760047888086,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T00:00:00Z","timestamp":1538092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pemphigus vulgaris (PV) is a relatively rare, potentially life\u2010threatening autoimmune disease that, in most cases, has an unknown etiology. Medications for hypertension have been linked to the onset and exacerbation of PV\u2010like symptoms. The diagnosis of medication\u2010related PV can be challenging because it has an identical appearance to the clinical and histologic appearance of idiopathic PV and cases may not resolve after discontinuation of the drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>We present a case of an elderly patient with gingival and cutaneous erosions, who underwent several medical and dental consultations without an appropriate diagnosis. After biopsy and a thorough review of her medical history, metoprolol was suspected as the offending agent. After consulting with her cardiologist, metoprolol was discontinued, and a complete resolution of all lesions resulted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, the current case is the first reported case of metoprolol\u2010induced PV in the English\u2010language literature. As such, it highlights the potential of medication involvement in some immune\u2010mediated diseases. Because the oral mucosa is often the first site of involvement in PV, knowledge of drug\u2010related PV is crucial in the diagnosis, treatment, and management of dental patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cap.10044","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T13:44:55Z","timestamp":1536241495000},"page":"24-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Metoprolol\u2010Induced Pemphigus\u2010Like Reaction"],"prefix":"10.1002","volume":"9","author":[{"given":"Seena","family":"Patel","sequence":"first","affiliation":[{"name":"Advanced Care Center and Special Needs Dentistry Arizona School of Dentistry &amp; Oral Health A.T. Still University  Mesa AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanna","family":"Kim","sequence":"additional","affiliation":[{"name":"Private practice  Orlando FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Allen","sequence":"additional","affiliation":[{"name":"Central Ohio Skin &amp; Cancer, Inc.  Westerville OH"},{"name":"College of Dentistry The Ohio State University  Columbus OH"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.01.022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12644"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12639"},{"key":"e_1_2_9_6_1","first-page":"1021","article-title":"A retrospective study of antihypertensives in pemphigus: a still unchartered odyssey particularly between thiols, amides and phenols","volume":"11","author":"Pietkiewicz P","year":"2015","journal-title":"Arch Med Sci"},{"key":"e_1_2_9_7_1","first-page":"751","article-title":"Pemphigus in a patient treated with penicillamine for Wilson's disease (in French)","volume":"76","author":"Degos R","year":"1969","journal-title":"Bull Soc Fr Dermatol Syphiligr"},{"issue":"6234","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/bmj.281.6234.194","article-title":"Captopril\u2010induced pemphigus","volume":"281","author":"Parfrey PS","year":"1980","journal-title":"Br Med J"},{"key":"e_1_2_9_9_1","first-page":"318","volume-title":"Oral and Maxillofacial Pathology","author":"Neville BW","year":"2016"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.79a.12017"},{"key":"e_1_2_9_11_1","first-page":"108","article-title":"Amoxicillin\/clavulanic acid\u2010induced pemphigus vulgaris: case report","volume":"20","author":"Baroni A","year":"2012","journal-title":"Acta Dermatovenerol Croat"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2007.00021"},{"key":"e_1_2_9_13_1","first-page":"746","article-title":"Bullous pemphigoid following therapy with an oral beta\u2010blocker","volume":"4","author":"Perry A","year":"2005","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90213-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/11530050-000000000-00000"}],"container-title":["Clinical Advances in Periodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcap.10044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cap.10044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:34:20Z","timestamp":1760045660000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/cap.10044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,28]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/cap.10044"],"URL":"https:\/\/doi.org\/10.1002\/cap.10044","archive":["Portico"],"relation":{},"ISSN":["2573-8046","2163-0097"],"issn-type":[{"type":"print","value":"2573-8046"},{"type":"electronic","value":"2163-0097"}],"subject":[],"published":{"date-parts":[[2018,9,28]]},"assertion":[{"value":"2018-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}