{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:57:42Z","timestamp":1781625462069,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T00:00:00Z","timestamp":1543536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The indications for augmentation of gingival tissue by connective tissue graft (CTG) are numerous. The techniques are widely adopted with extensive literature reporting high success. Harvest techniques include the mid to anterior palate, versus the posterior palate and tuberosity. The latter comprises denser collagen, identified as a more suitable graft. Alas, rarely have hyperplastic responses been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>Two adult, Caucasian patients presented with clinical need for soft tissue augmentation. Autogenous tissue was opted for, harvesting from the tuberosity gingiva. De\u2010epithelialized outside the mouth and inserted into envelope flaps, late healing resulted in hyperplastic gingival lesions. Neither lesion could be successfully removed, and biopsy for histopathological investigation was carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hyperplastic response resulting from soft tissue augmentation with tuberosity CTG is rare but may occur. Laser or scalpel might not ensure complete removal. Informing the patient of this rare adverse effect may be important.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cap.10047","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T06:17:58Z","timestamp":1537078678000},"page":"50-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hyperplastic Response Following Soft Tissue Augmentation in the Esthetic Zone"],"prefix":"10.1002","volume":"9","author":[{"given":"Howard","family":"Gluckman","sequence":"first","affiliation":[{"name":"Private practice of periodontics and oral medicine \u2013 The Implant Clinic The Implant &amp; Aesthetic Academy  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Du Toit","sequence":"additional","affiliation":[{"name":"Resident Department of Periodontics and Oral Medicine University of Pretoria  Pretoria South Africa"},{"name":"The Implant &amp; Aesthetic Academy  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Cruvinel","family":"Pontes","sequence":"additional","affiliation":[{"name":"The Implant &amp; Aesthetic Academy  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"Hille","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology University of the Western Cape  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(80)90090-6"},{"key":"e_1_2_9_3_1","first-page":"279","article-title":"A single\u2010incision technique to harvest subepithelial connective tissue grafts from the palate","volume":"19","author":"Hurzeler MB","year":"1999","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12185"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12178"},{"key":"e_1_2_9_6_1","first-page":"221","article-title":"Soft tissue management for dental implants: what are the most effective techniques? 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