{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:54:33Z","timestamp":1760061273498,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T00:00:00Z","timestamp":1588550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Management of drug\u2010influenced gingival enlargement is challenging, and surgery is most often indicated. However, because of a unique mechanism of action, azithromycin helps in the management of gingival enlargement caused by cyclosporine. An incidental observation of the effect of azithromycin in the cyclosporine\u2010influenced gingival enlargement by physicians in 1995 led to series of basic investigations and clinical trials confirming this observation and providing a non\u2010surgical treatment modality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>In this report, successful management of cyclosporine\u2010influenced gingival enlargement in a 39\u2010year\u2010old renal transplant patient with the use of azithromycin without any surgical intervention is presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Use of azithromycin for managing cyclosporine\u2010influenced gingival enlargement is a useful alternative or adjunct to surgical management. It is hoped that this report will raise further awareness of this non\u2010surgical modality in patients taking cyclosporine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cap.10097","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T16:49:17Z","timestamp":1582130957000},"page":"140-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Management of Cyclosporine\u2010Influenced Gingival Enlargement With Azithromycin"],"prefix":"10.1002","volume":"10","author":[{"given":"Satish S.","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Periodontics, Arizona School of Dentistry and Oral Health A. T. Still University  Mesa AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Husain","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry University of Kuwait  Kuwait"},{"name":"Department of Periodontics Ministry of Health  Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kian","family":"Kar","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Diagnostic Sciences and Dental Hygiene, Herman Ostrow School of Dentistry University of Southern California  Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01878.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240460209"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.00986.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808701110"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb01698.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.7.671"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.6.587"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503163321116"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199806270-00012"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.12.2694"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1397-3142.2003.00067.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.09.059"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/08860220701263580"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-8-34"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12264"}],"container-title":["Clinical Advances in Periodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcap.10097","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cap.10097","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cap.10097","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cap.10097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T22:13:43Z","timestamp":1760048023000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/cap.10097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,4]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/cap.10097"],"URL":"https:\/\/doi.org\/10.1002\/cap.10097","archive":["Portico"],"relation":{},"ISSN":["2573-8046","2163-0097"],"issn-type":[{"type":"print","value":"2573-8046"},{"type":"electronic","value":"2163-0097"}],"subject":[],"published":{"date-parts":[[2020,5,4]]},"assertion":[{"value":"2019-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}