{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:53:00Z","timestamp":1760061180278,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Maturity onset diabetes of the young (MODY) is a rare form of diabetes mellitus resulting from single nucleotide polymorphisms. There is a lack of evidence describing their periodontal condition and the management of these patients. The objective of this case report is to present the 6\u2010month outcomes following non\u2010surgical periodontal treatment of a patient diagnosed with MODY 5, the Renal Cyst and Diabetes Syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>This case report describes the periodontal presentation and non\u2010surgical management of a 21\u2010year\u2010old patient, diagnosed with hyperglycemia (HbA1c &gt;14%) and stage 4 chronic kidney disease. She presented with generalized severe chronic periodontitis and multiple periodontal abscesses. She was treated with quadrant debridement with adjunctive systemic amoxicillin and metronidazole and 0.2% chlorhexidine mouth rinse. Significant improvement was observed after treatment, remaining stable 6\u2010month post\u2010treatment, with only two sites with probing depths \u22655 mm. This was consistent with a reduction of the periodontal inflamed surface area from 3165 to 500\u00a0mm<jats:sup>2<\/jats:sup>. HbA1c was also reduced to 8.7% 6 months after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MODY patients presenting with periodontitis can be successfully treated non\u2010surgically, concurrent with diabetic management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cap.10114","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T16:53:31Z","timestamp":1595523211000},"page":"64-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Maturity Onset Diabetes of the Young and Generalized Stage III Grade C Periodontitis: A Case Report"],"prefix":"10.1002","volume":"11","author":[{"given":"Ren Jie Jacob","family":"Chew","sequence":"first","affiliation":[{"name":"Discipline of Periodontics Faculty of Dentistry National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoe Kit","family":"Chee","sequence":"additional","affiliation":[{"name":"Periodontics Unit Department of Restorative Dentistry National Dental Centre Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2342-y"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.134005"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.06.014"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120255"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12235"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S179793"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12772"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2014-0384"},{"key":"e_1_2_11_10_1","first-page":"3326","article-title":"Systematic review of TCF2 anomalies in renal cysts and diabetes syndrome\/maturity onset diabetes of the young type 5","volume":"123","author":"Chen YZ","year":"2010","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12729"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12945"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01249.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12947"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00994.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12808"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13044"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.9.1395"}],"container-title":["Clinical Advances in Periodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcap.10114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cap.10114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cap.10114","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cap.10114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:15:43Z","timestamp":1760044543000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/cap.10114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,13]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/cap.10114"],"URL":"https:\/\/doi.org\/10.1002\/cap.10114","archive":["Portico"],"relation":{},"ISSN":["2573-8046","2163-0097"],"issn-type":[{"type":"print","value":"2573-8046"},{"type":"electronic","value":"2163-0097"}],"subject":[],"published":{"date-parts":[[2020,8,13]]},"assertion":[{"value":"2020-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}