{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:02:03Z","timestamp":1760140923669,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Guided tissue regeneration (GTR) has been well documented with combination of bone graft substitutes and biologic modifiers to improve the outcomes of periodontal regenerative procedures. Amnion\u2010chorion allograft membrane (ACM) is a placenta\u2010derived resorbable allograft membrane which contains growth factors found in the placenta. The primary purpose of the barrier membranes for GTR was to exclude the epithelial down\u2010growth along with the root surface, however, the ACM can be used as an additional biologic modifier because of the release of growth factors from the ACM after placement. The aim of this case report is to evaluate the efficacy and the application of ACM on the previously diseased root surface to treat periodontal intrabony defect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 60\u2010year\u2010old Caucasian male with deep and wide intrabony defect on mesial #19 was treated with a regenerative procedure with combination of application of ACM on the root surface and filling the intrabony defect with the corticocancellous freeze\u2010dried bone allograft. The bone substitute was covered with another layer of ACM and primary closure was achieved. Wound healing process was uneventful, and the clinical and radiographic outcomes were favorable up to 18 months after the surgical procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case report demonstrated that the application of ACM on the root surface with a combination of bone substitute might enhance to the radiographic bone fill and the clinical attachment level gain and minimize the risk of post\u2010operative gingival recession.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cap.10125","type":"journal-article","created":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T11:38:34Z","timestamp":1598787514000},"page":"195-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Amnion\u2013Chorion Allograft Barrier Used on Root Surface for Regenerative Procedures: Case Report"],"prefix":"10.1002","volume":"10","author":[{"given":"Yusuke","family":"Hamada","sequence":"first","affiliation":[{"name":"Department of Periodontology Indiana University School of Dentistry  Indianapolis IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Ting","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Periodontology Creighton University School of Dentistry  Omaha NE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven B.","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Department of Periodontology Indiana University School of Dentistry  Indianapolis IN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1979.50.7.355"},{"key":"e_1_2_9_3_1","first-page":"385","article-title":"Which biomaterials may promote periodontal regeneration in intrabony periodontal defects? 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