{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:08:39Z","timestamp":1760141319878,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Endodontic\u2010periodontal combined lesions pose a treatment challenge for clinicians, especially when the lesion is persistent and does not show signs of healing after initial endodontic treatment. This case report describes interdisciplinary management of a non\u2010healing combined endodontic\u2010periodontal lesion related to a peri\u2010apical cyst, through a combined approach of apicoectomy and guided tissue regeneration (GTR) with enamel matrix derivative (EMD). Most documented cases have been treated in a sequential manner, with minimal literature present on the effects of a combined approach utilizing EMD for the treatment of these lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 72\u2010year\u2010old male patient presented with an endodontic\u2010periodontal lesion at tooth #31 initially treated with nonsurgical root canal therapy. The lesion was not responsive to initial endodontic treatment. The patient was informed of questionable prognosis, however wished to save the tooth. Tooth #31 was treated via a combination approach of apicoectomy with bioceramic putty retrograde filling, followed by GTR of the defect using allograft, EMD, and resorbable barrier membrane. The lesion was biopsied and diagnosed as a periapical cyst. Clinical and radiographic examination at 1 year showed resolution of lesion, reduction in probing depths, and good bone fill of the defect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Traditionally, endodontic\u2010periodontal lesions, which were not responsive to initial therapy, would be given a questionable prognosis and be extracted. This case demonstrates that non\u2010healing, peri\u2010apical lesions may be cystic in nature and effectively managed utilizing a combined approach, with apicoectomy and GTR with EMD, to produce a stable outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cap.10149","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T04:54:08Z","timestamp":1612587248000},"page":"94-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Resolution of a Cystic Endodontic\u2010Periodontal Lesion Utilizing Combined Apicoectomy and Guided Tissue Regeneration: A Case Report"],"prefix":"10.1002","volume":"12","author":[{"given":"Howard H.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dental Medicine, Stony Brook University  Stony Brook New York USA"},{"name":"Private Practice  Forest Hills New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine, Stony Brook University  Stony Brook New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivas R.","family":"Myneni","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine, Stony Brook University  Stony Brook New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290801.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.16-0642"},{"key":"e_1_2_10_4_1","first-page":"CD005511","article-title":"Endodontic procedures for retreatment of periapical lesions","volume":"10","author":"Del Fabbro M","year":"2016","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2007.01322.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2002.00568.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.04.008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01099.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.02.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.01.004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.05.016"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12265"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12638"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.266"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.3.450"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.06.004"}],"container-title":["Clinical Advances in Periodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cap.10149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cap.10149","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cap.10149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:49:09Z","timestamp":1760057349000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/cap.10149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,26]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1002\/cap.10149"],"URL":"https:\/\/doi.org\/10.1002\/cap.10149","archive":["Portico"],"relation":{},"ISSN":["2573-8046","2163-0097"],"issn-type":[{"type":"print","value":"2573-8046"},{"type":"electronic","value":"2163-0097"}],"subject":[],"published":{"date-parts":[[2021,2,26]]},"assertion":[{"value":"2020-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}