{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T18:59:16Z","timestamp":1769626756373,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The purpose of this case report is to present endodontic and periodontal management of mucosal fenestrations with exposed root apices. The treatment protocol in present cases includes a combination of regenerative therapy using platelet\u2010rich fibrin (PRF) with connective tissue graft (CTG) and endodontic microsurgery. Pre\u2010existing condition of these teeth exhibits apical lesion with prominent root position and complete buccal bone dehiscence\/fenestration presents a true challenge to successful outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>Four patients having concomitant mucosal fenestrations with an apical lesion and complete denudation\/fenestration of the buccal plate were treated with root canal treatment and then by endodontic microsurgery. After the root\u2010end resection and retrograde filling, PRF was placed in the bone defect maintaining intimate contact with the bone surface. CTG was harvested from the palate, placed over the PRF, and beneath the flap corresponding to the mucosal fenestration defect, and sutured with the flap to ensure a secured position. The flap was then repositioned and sutured. All patients showed the complete coverage of the mucosal fenestration with no post\u2010operative complications and were followed up to 2\u20135 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Peri\u2010radicular endodontic microsurgery and CTG along with PRF may be used as a predictable treatment option to manage the mucosal fenestrations in such challenging cases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cap.10194","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T13:04:42Z","timestamp":1643288682000},"page":"194-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Management of Isolated Labial Mucosal Fenestration by Endodontic Microsurgery Along With Platelet\u2010Rich Fibrin and Connective Tissue Graft: A Series of Four Cases"],"prefix":"10.1002","volume":"12","author":[{"given":"Shikha","family":"Tewari","sequence":"first","affiliation":[{"name":"Department of Periodontics Post Graduate Institute of Dental Sciences  Rohtak Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenu","family":"Dhiman","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Shaheed Hasan Khan Mewati Government Medical College, Nuh, Haryana, India; formerly, Department of Conservative Dentistry and Endodontics Post Graduate Institute of Dental Sciences  Rohtak Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subramony","family":"Bhagavatheeswaran","sequence":"additional","affiliation":[{"name":"Department of Periodontics Post Graduate Institute of Dental Sciences  Rohtak Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidhi","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Post Graduate Institute of Dental Sciences  Rohtak Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Tewari","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Post Graduate Institute of Dental Sciences  Rohtak Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(71)90292-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.6.722"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2008.01463.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.06.012"},{"issue":"2","key":"e_1_2_9_6_1","first-page":"437","article-title":"Combined mucosal and alveolar fenestration: A clinical report and literature review","volume":"54","author":"Nimigean VR","year":"2013","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.11.020"},{"issue":"5","key":"e_1_2_9_8_1","first-page":"425","article-title":"Isolated mucosal fenestration with localized gingival recession: Closure with an acellular dermal graft. 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