{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:45:14Z","timestamp":1788511514384,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2023,6]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Collagen matrices have been used as connective tissue graft (CTG) substitutes. However, they do not have the same efficacy compared to CTG. Adding biological agents may increase collagen matrices' efficacy. The present case reports the use of a biofunctionalized volume\u2010stable collagen matrix (VCMX) with injectable platelet\u2010rich fibrin (iPRF) associated with the coronally advanced flap (CAF) to treat single gingival recession (GR) defect.<\/jats:p><\/jats:sec>Case Presentation<\/jats:title>A Recession Type 1 (RT1 A\u2010) defect at maxillary left canine in a male patient was treated using a VCMX biofunctionalized with iPRF associated with CAF. No swelling or edema was observed during the first 14 days after surgery. Complete root coverage was observed (RecRed of 4.0 mm) after 6 months. Gingival thickness (GT) increased (1.0 mm) by the end of the follow\u2010up.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The present case report shows that CAF associated with VCMX+iPRF presents good clinical outcomes for single GR defect.<\/jats:p><\/jats:sec>Key points<\/jats:title>Why is this case new information?<\/jats:bold>\n\nThis case is the first one to our knowledge to describe the biofunctionalization of VCMX with iPRF to treat single gingival recession.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>What are the keys to successful management of this case?<\/jats:bold>\n\nProper material handling.<\/jats:p><\/jats:list-item>\nProper iPRF protocol execution.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>What are the primary limitations to success in this case?<\/jats:bold>\n\nNeed of venipuncture.<\/jats:p><\/jats:list-item>\nCorrect preparation of VCMX+iPRF.<\/jats:p><\/jats:list-item>\nPatient compliance.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/cap.10207","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T08:40:04Z","timestamp":1653295204000},"page":"110-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Collagen matrix biofunctionalized with injectable platelet\u2010rich fibrin for the treatment of single gingival recession: A case report"],"prefix":"10.1002","volume":"13","author":[{"given":"Mauro Pedrine","family":"Santamaria","sequence":"first","affiliation":[{"name":"Division of Periodontics, Institute of Science and Technology S\u00e3o Paulo State University (Unesp) S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"},{"name":"College of Dentistry University of Kentucky Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Rossato","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Institute of Science and Technology S\u00e3o Paulo State University (Unesp) S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00eds Fernanda","family":"Ferreira Ferraz","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Institute of Science and Technology S\u00e3o Paulo State University (Unesp) S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Bonaf\u00e9","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Institute of Science and Technology S\u00e3o Paulo State University (Unesp) S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela Maria Viana","family":"Miguel","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Institute of Science and Technology S\u00e3o Paulo State University (Unesp) S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Pereira","family":"Nunes","sequence":"additional","affiliation":[{"name":"Proimperio Institute S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160391"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12182"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12834"},{"key":"e_1_2_9_5_1","first-page":"259","article-title":"Effect of xenogeneic dermal matrix associated with coronally advanced flap in the treatment of single gingival recessions: a case 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