{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:59:27Z","timestamp":1792036767931,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T00:00:00Z","timestamp":1666569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>With technological advancements in reconstructive periodontology, traditional protocols for the treatment of gingival recessions (GRs) can be challenged. This manuscript presents preliminary findings of a novel minimally\u2010invasive approach for the regenerative treatment of multiple adjacent GR defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two healthy adults were treated as part of this study. Multiple adjacent GRs in both subjects (1 in the mandible, and 1 in the maxilla) were treated employing a tunneled coronally advanced flap (TCAF) design, with the application of a cross\u2010linked collagen matrix (CCM) that was enriched with recombinant human platelet\u2010derived growth factor\u2010BB (PDGF\u2010BB) that was also applied on the prepared root surfaces. Clinical, ultrasonographic, esthetic, and patient\u2010reported outcomes were observed at approximately 6\u2010 and 18\u2010month time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All sites healed uneventfully after the treatments. Complete root coverage was achieved and maintained throughout the follow\u2010up observations, from 6 to 18 months. Patients reported minimal discomfort and reduction of dentinal hypersensitivity at the augmented sites. The areas augmented with CCM + PDGF\u2010BB revealed an increased soft tissue thickness relative to baseline (pretreatment) measures, as well as reduction in the level of the facial bone dehiscences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This article describes the success of two cases of a novel minimally invasive regenerative approach for the treatment of multiple adjacent GR defects by the TCAF, using a CCM loaded with PDGF\u2010BB. This approach offers potential as a minimally\u2010invasive method to repair multiple adjacent GRs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cap.10211","type":"journal-article","created":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T04:14:20Z","timestamp":1654316060000},"page":"224-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["PDGF\u2010BB\u2010enriched collagen matrix to treat multiple gingival recessions with the tunneled coronally advanced flap"],"prefix":"10.1002","volume":"12","author":[{"given":"Shayan","family":"Barootchi","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Center for clinical Research and evidence synthesis In oral TissuE RegeneratION (CRITERION)  Ann Arbor Michigan USA"},{"name":"Center for clinical Research and evidence synthesis In oral TissuE RegeneratION 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