{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:50:13Z","timestamp":1760061013899,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Necrotizing periodontitis (NP) is a rare form of periodontal disease. It can manifest in immunocompromised patients and present as painful and rapidly progressing destruction with necrotic and ulcerated periodontal tissues. This case report describes a rare case of severe NP in human immunodeficiency virus (HIV)\u2010positive patient including medical management and periodontal treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 28\u2010year\u2010old male presented to the periodontal clinic with chief complaint of severe oral pain leading to loss of chewing ability, spontaneous gingival bleeding, generalized gingival recession, tooth mobility, and dentinal hypersensitivity. Clinical and radiographic examination revealed generalized tissue necrosis with severe periodontal destruction, extensive bleeding, spontaneous suppuration, and heavy biofilm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Medical history was positive for perinatal HIV infection, which was treated and patient was asymptomatic until he discontinued antiviral medications nine years ago. Following initial examination, patient was referred to the Infectious disease clinic and multidisciplinary management was initiated with comprehensive management of primary disease including systemic antiviral, antibiotic, and antifungal therapy to establish immunocompetence compatible with providing mechanical nonsurgical periodontal treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This case report highlights a severe and generalized form of NP in an HIV patient due to the cessation of antiviral therapy. Favorable course of interdisciplinary medical and periodontal therapy resulted in significant improvement in patient's systemic, oral, and periodontal health.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cap.10252","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T05:27:00Z","timestamp":1686720420000},"page":"127-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic management and periodontal treatment of HIV\u2010necrotizing periodontitis: A case report"],"prefix":"10.1002","volume":"14","author":[{"given":"Janina","family":"Golob Deeb","sequence":"first","affiliation":[{"name":"Department of Periodontics Virginia Commonwealth University Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Elnakka","sequence":"additional","affiliation":[{"name":"Department of Periodontics Virginia Commonwealth University Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George R","family":"Deeb","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Virginia Commonwealth University Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12941"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02419.x"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"98","article-title":"The severity, extent and recurrence of necrotizing periodontal disease in relation to HIV status and CD4+ T cell count","volume":"12","author":"Phiri R","year":"2010","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.20396\/bjos.v16i0.8651054"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.50888"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.05.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.93470"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.02011.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.12.1790"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324872"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdj.2015.07.001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13735"},{"issue":"1","key":"e_1_2_8_14_1","first-page":"71","article-title":"Necrotizing periodontal diseases in HIV\u2010infected Brazilian patients: a clinical and microbiologic descriptive study","volume":"43","author":"Ramos MP","year":"2012","journal-title":"Quintessence Int"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.09.004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cap.10105"},{"key":"e_1_2_8_17_1","unstructured":"Virginia Department of Health.Virginia HIV Surveillance Annual Report. Updated December 20 2022. Accessed May 18 2023.https:\/\/www.vdh.virginia.gov\/content\/uploads\/sites\/10\/2022\/05\/HIV\u2010Annual_Report_Update_2021.pdf"},{"key":"e_1_2_8_18_1","unstructured":"MartinEL Capus Executive Summary: Virginia Department of Health. 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