{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:50:27Z","timestamp":1782589827656,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This 6\u2010month randomized split\u2010mouth and placebo\u2010controlled clinical trial aimed to evaluate the clinical and radiographic efficacy of adjunctive use of 0.05% zoledronate (ZLN) gel as local drug delivery to scaling and root planing (SRP) in stage III, grade B periodontitis patients with and without controlled type\u20102 diabetes mellitus (DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 120 infrabony sites were divided into two groups: Group\u20101 (non\u2010diabetic periodontitis) and Group\u20102 (periodontitis +\u00a0DM). A total of 60 sites in each group were randomized to receive treatment with SRP\u00a0+\u00a0placebo gel (control) or SRP\u00a0+\u00a00.05% ZLN gel (test). Plaque index (PI), modified sulcus bleeding index (mSBI), pocket probing depth (PPD), and relative attachment levels (RAL) were assessed at baseline, 3 and 6 months, and digital intraoral periapical and cone\u2010beam computed tomography imaging were used to measure the linear and percentage reduction of intrabony defect depth (DD, DDR%) after 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Group\u20101 showed significant reduction in PI (0.56\u00a0\u00b1\u00a00.15 and 0.52\u00a0\u00b1\u00a00.19 from 0.67\u00a0\u00b1\u00a00.17), mSBI (0.7\u00a0\u00b1 0.60 and 0.47\u00a0\u00b1 0.57 from 0.9\u00a0\u00b1\u00a00.48), PPD (4.6\u00a0\u00b1 0.85 and 3.43 \u00b1 0.63 from 6.5\u00a0\u00b1\u00a01.04) and gain in RAL (7.03\u00a0\u00b1\u00a00.85 and 5.93 \u00b1 0.69 from 8.9\u00a0\u00b1\u00a01.09) in the ZLN\u2010treated sites than the placebo sites and also from Group\u20102 sites after 3 and 6 months, respectively. A significant reduction in DD of 28.79% in Group\u20101 and 22.20% in Group\u20102 at ZLN sites was seen compared to placebo sites of both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ZLN gel applied subgingivally in infrabony pockets resulted in significant clinical improvements evident by probing depth reduction and gain in attachment levels along with radiographic evidence of more bone fill seen in non\u2010diabetic patients compared to diabetic periodontitis patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cap.10262","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T02:30:58Z","timestamp":1689906658000},"page":"211-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparative evaluation of the clinical and radiographic efficacy of 0.05% zoledronate gel as local drug delivery system in treating intrabony defects in stage III grade B periodontitis patients with and without type\u20102 diabetes mellitus\u2014A randomized split\u2010mouth clinical trial"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2478-077X","authenticated-orcid":false,"given":"Subash Chandra","family":"Raj","sequence":"first","affiliation":[{"name":"Department of Periodontics S.C.B Dental College and Hospital Cuttack Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6012-7984","authenticated-orcid":false,"given":"Asit Kumar","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Periodontics S.C.B Dental College and Hospital Cuttack Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5768-0962","authenticated-orcid":false,"given":"Devapratim","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Periodontics S.C.B Dental College and Hospital 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