{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:45:12Z","timestamp":1788511512486,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Connective tissue graft substitutes have been used widely to overcome autogenous graft limitations. Nevertheless, they do not provide comparable results in the treatment of periodontal and peri\u2010implant soft tissue defects. Based on the principles of tissue\u2010engineered materials, injectable platelet\u2010rich fibrin (i\u2010PRF) has been combined with collagen matrices (CMs) to enhance their clinical efficacy. To the best of our knowledge, this is the first case series demonstrating the use of i\u2010PRF for the biofunctionalization of a volume\u2010stable collagen matrix (VCMX) as an adjunct to coronally advanced flap (CAF) to treat single gingival recession (GR) defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods &amp; Results<\/jats:title><jats:p>The study included 10 patients. Bleeding on probing, probing depth, GR height, clinical attachment level, esthetics, and dentin hypersensitivity were evaluated. After 6 months, a significant GR reduction (RecRed: 2.15 \u00b1 0.7\u00a0mm; <jats:italic>p<\/jats:italic> = 0.005) and percentage of root coverage (% RC) of 81.13% were observed. Additionally, 40% of the sites showed complete root coverage. Gingival thickness increased 0.64\u00a0mm. Patient\u2010centered evaluations demonstrated dentin hypersensitivity and esthetics improvements by the end of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VCMX biofunctionalized with i\u2010PRF associated with CAF technique showed promising clinical outcomes in the treatment of single RT1 GR defects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cap.10276","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T02:42:14Z","timestamp":1702435334000},"page":"180-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Treatment of single gingival recessions using biofunctionalized collagen matrix: A case series"],"prefix":"10.1002","volume":"14","author":[{"given":"Amanda","family":"Rossato","sequence":"first","affiliation":[{"name":"Division of Periodontics S\u00e3o Paulo State University (Unesp), Institute of Science and Technology, S\u00e3o Jos\u00e9 dos Campos \u2010 S\u00e3o Paulo  San Francisco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela Maria Viana","family":"Miguel","sequence":"additional","affiliation":[{"name":"Division of Periodontics S\u00e3o Paulo State University (Unesp), Institute of Science and Technology, S\u00e3o Jos\u00e9 dos Campos \u2010 S\u00e3o Paulo  San Francisco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Ferreira","family":"Bonaf\u00e9","sequence":"additional","affiliation":[{"name":"Division of Periodontics S\u00e3o Paulo State University (Unesp), Institute of Science and Technology, S\u00e3o Jos\u00e9 dos Campos \u2010 S\u00e3o Paulo  San Francisco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid Fernandes","family":"Mathias\u2010Santamaria","sequence":"additional","affiliation":[{"name":"College of Dentistry \u2010 Lexington University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Pereira","family":"Nunes","sequence":"additional","affiliation":[{"name":"Proimperio Institute \u2010 S\u00e3o Paulo  San Francisco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Pedrine","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Division of Periodontics S\u00e3o Paulo State University (Unesp), Institute of Science and Technology, S\u00e3o Jos\u00e9 dos Campos \u2010 S\u00e3o Paulo  San Francisco Brazil"},{"name":"College of Dentistry \u2010 Lexington University of Kentucky  Lexington Kentucky 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