{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:54:47Z","timestamp":1781582087349,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic granulomatous disease (CGD) is an inborn error of immunity characterized by life\u2010threatening infections and inflammation. Allogeneic hematopoietic stem cell transplantation (alloHSCT) is potentially curative. Necrotizing periodontal diseases (NPDs) are rare and can be seen in immunocompromised\/immunosuppressed individuals but have not been reported in patients with CGD. We report NPD in the form of necrotizing stomatitis (NS) in a patient transplanted for CGD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A 12\u2010year\u2010old male presented with severe gingival pain. The patient's medical history was significant for X\u2010linked CGD diagnosed at 4 years of age and a heterozygous\n                      <jats:italic>RIPK1<\/jats:italic>\n                      mutation. The patient underwent alloHSCT from a mismatched unrelated donor. Intraoral examination on day +61 post\u2010alloHSCT revealed multifocal gingival ulceration, which did not respond to a short course of prednisone and topical dexamethasone oral solution. The ulcers progressed to involve the lip mucosa and soft palate\/tonsil (day +88).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Biopsy from the soft palate\/tonsillar area showed deep acute inflammation and abscesses consistent with the diagnosis of NS. The patient underwent deep gingival scaling on day +103 and received amoxicillin and metronidazole. The patient had complete resolution of the oral ulcers by day +125 but developed chronic graft\u2010versus\u2010host disease involving the oral mucosa on day +314 post\u2010alloHSCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We report the first case of NS as a complication of alloHSCT in a patient transplanted for CGD which was successfully managed with antibiotic therapy, periodontal debridement, and discontinuation of potentially triggering agents. Our report demonstrates that NS\/NPD may occur in post\u2010alloHSCT setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Chronic granulomatous disease is an inherited multisystem autoinflammatory condition.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Patients with chronic granulomatous disease may have oral manifestations including oral ulcerations and gingivitis\/periodontitis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Necrotizing ulcerative stomatitis may arise in the post\u2010hematopoietic stem cell transplantation setting.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain language summary<\/jats:title>\n                    <jats:p>Chronic granulomatous disease (CGD) is a condition that impairs the immune system and can be managed with bone marrow transplantation. Necrotizing periodontal disease (NPD) are a group of rare conditions that affect the mouth and cause tissue death (necrosis) and present clinically as oral ulcers (mouth sores). In this article, we report NPD in a child who received bone marrow transplantation for his CGD. This report broadens the differential diagnosis of oral ulcers in the post\u2010transplant setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cap.10363","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T14:29:53Z","timestamp":1753712993000},"page":"314-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Necrotizing ulcerative stomatitis following bone marrow transplantation in a patient with chronic granulomatous disease: Case report"],"prefix":"10.1002","volume":"16","author":[{"given":"Lama","family":"Alabdulaaly","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"},{"name":"Maxillofacial Surgery and Diagnostic Sciences Department College of Dentistry King Saud bin Abdulaziz University for Health Sciences  Riyadh Saudi Arabia"},{"name":"King Abdulaziz Medical City Ministry of National Guard Health Affairs  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy","family":"Lucas","sequence":"additional","affiliation":[{"name":"Dana Farber\/Boston Children's Hospital Center for Cancer and Blood Disorders  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Prockop","sequence":"additional","affiliation":[{"name":"Dana Farber\/Boston Children's Hospital Center for Cancer and Blood Disorders  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Pathology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Treister","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"},{"name":"Division of Oral Medicine and Dentistry Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herve","family":"Sroussi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"},{"name":"Division of Oral Medicine and Dentistry Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1959.02070010389004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldw009"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010020\u201008800\u2010x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792\u2010200005000\u201000003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu1154"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2012.11.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109761"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010023\u201001541\u20104"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005234"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.2.462"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.09.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1228161"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000021"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17\u20100721"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.16\u20100642"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001556"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.11.990"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12022"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756\u20100500\u20103\u201037"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.07.050"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.10.611"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.1985.tb00478.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(81)90032\u20103"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1978.0078"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.20.3.431"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1813582116"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1041315"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010024\u201001707\u20108"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000151038.82538.de"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000060573"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102015\u2010211092"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2011.07.012"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1983.02140320068015"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.04.026"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8876847"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12947"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17\u20100733"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(78)90313\u20104"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u2010051x.2001.028006589.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01065"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.109112"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.04.014"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.07.035"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010019\u201000659\u20108"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar2641"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.05.002"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010017\u20100775\u20104"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020035"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406207231152644"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.10.011"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882\u2010018\u20100764\u2010z"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20101042"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2008250"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01086"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.06.009"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1975.46.12.715"}],"container-title":["Clinical Advances in Periodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cap.10363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cap.10363","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cap.10363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:39:27Z","timestamp":1781581167000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/cap.10363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/cap.10363"],"URL":"https:\/\/doi.org\/10.1002\/cap.10363","archive":["Portico"],"relation":{},"ISSN":["2573-8046","2163-0097"],"issn-type":[{"value":"2573-8046","type":"print"},{"value":"2163-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]},"assertion":[{"value":"2024-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}