{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:28:41Z","timestamp":1782307721867,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Molar incisor pattern periodontitis (MIPP) poses many challenges in the field of periodontics. Emerging evidence has shown\u00a0promising results in regenerative therapy while treating such a patient population. The present case study demonstrates an effective implementation of recombinant human platelet\u2010derived growth factor (rh\u2010PDGF) for the successful regeneration of infrabony defects associated with MIPP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 17\u2010year\u2010old\u00a0African\u2010American\u00a0male patient presented to the Periodontics Clinic at Nova Southeastern University, requiring periodontal evaluation prior to the initiation of orthodontic therapy.\u00a0Upon examination, the patient was diagnosed as a localized stage III, grade C MIPP. Initially, the patient underwent phase I therapy. Subsequently, surgeries consisted of regenerative procedures including\u00a0a combination of\u00a0allograft bone graft, rh\u2010PDGF, and collagen membrane.\u00a0The patient was seen for regular follow\u2010ups and supportive periodontal therapy during the healing periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The regenerative procedures resulted in significant improvement in all periodontal parameters, including probing depth, clinical attachment level, radiographic bone levels, and clinical and radiographic furcation closure, allowing the patient to retain all compromised teeth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of surgical debridement with rh\u2010PDGF serves as a plausible treatment approach for infrabony defects in patients with MIPP. Further investigation through well\u2010designed randomized controlled clinical trials is warranted to provide clearer insights.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Point<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>rh\u2010PDGF combined with an allograft is a successful treatment option in MIPP patients.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary<\/jats:title>\n                    <jats:p>Molar incisor pattern periodontitis (MIPP) is a severe form of periodontal disease, often affecting specific teeth in the periodontium of young patients. The nature of the disease requires early diagnosis and treatment to avoid potential complications, including tooth loss. This case report highlights the diagnosis and management of a patient with MIPP affecting seven teeth. Upon completion of the referral to the Periodontics Department at Nova Southeastern University, the patient was treatment planned for phase 1 therapy, including oral hygiene instructions, localized deep cleaning, and reevaluation of results in a short follow\u2010up. Following the reevaluation appointment, the patient underwent a surgical phase via regenerative therapies utilizing bone grafts, biologics, and membranes. All surgical procedures resulted in significant improvements in clinical and radiographic parameters and remained stable over a 2\u2010year follow\u2010up period. This case report highlights the successful use of rh\u2010PDGF in the treatment of MIPP\u2010associated periodontal defects. Further investigation through well\u2010designed clinical trials is warranted to provide clearer insights.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cap.70022","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:41:20Z","timestamp":1759880480000},"page":"387-394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effective treatment of a molar\u2010incisor pattern periodontitis patient utilizing recombinant human platelet\u2010derived growth factor: A case report"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8827-0256","authenticated-orcid":false,"given":"Arsalan","family":"Danesh","sequence":"first","affiliation":[{"name":"Department of Periodontology College of Dental Medicine Nova Southeastern University  Davie Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7765-3905","authenticated-orcid":false,"given":"Arman","family":"Danesh","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine and Oral Health Sciences McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8804-4843","authenticated-orcid":false,"given":"Saynur","family":"Vardar","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dental Medicine Nova Southeastern University  Davie Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5656-7685","authenticated-orcid":false,"given":"Theofilos","family":"Koutouzis","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dental Medicine Nova Southeastern University  Davie Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2019.07.024"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140171"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12630"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12186107"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2020.04.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13409"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.22\u20100361"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.7453\/gahmj.2013.008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12935"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2010.01538.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1998.tb02455.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1989.tb01626.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010017\u20102139\u2010y"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.9.1282"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1902\/jop.2015.140379","article-title":"Periodontal regeneration\u2013furcation defects: a consensus report from the AAP Regeneration Workshop","volume":"86","author":"Reddy MS","year":"2015","journal-title":"J Periodontol"}],"container-title":["Clinical Advances in Periodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cap.70022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:04:23Z","timestamp":1767855863000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/cap.70022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,7]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/cap.70022"],"URL":"https:\/\/doi.org\/10.1002\/cap.70022","archive":["Portico"],"relation":{},"ISSN":["2573-8046","2163-0097"],"issn-type":[{"value":"2573-8046","type":"print"},{"value":"2163-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,7]]},"assertion":[{"value":"2025-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}