{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:15:37Z","timestamp":1778138137475,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiotherapy for head and neck cancer is associated with adverse oral effects, including salivary gland hypofunction, radiation\u2010related caries, and periodontal tissue alterations, which negatively impact oral health and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 56\u2010year\u2010old male previously treated with surgery, radiotherapy, and chemotherapy for oropharyngeal cancer presented with dentin hypersensitivity, gingival recession, and reduced keratinized tissue. A multidisciplinary rehabilitation was performed, including non\u2010surgical periodontal therapy, free gingival grafting, restorative treatment of cervical lesions, prosthetic rehabilitation, and individualized preventive maintenance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Uneventful healing was observed at all surgical sites. The free gingival grafts resulted in increased keratinized tissue and vestibular depth, with stable periodontal conditions and resolution of dentin hypersensitivity. Clinical stability was maintained throughout a 24\u2010month follow\u2010up period, with no adverse radiation\u2010related effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Multidisciplinary oral rehabilitation, including mucogingival surgery and preventive care, can be safely and effectively performed in irradiated patients, improving periodontal stability, oral comfort, and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Head and neck radiotherapy can cause long\u2010lasting oral complications that require careful and individualized dental management.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Periodontal surgery, restorative treatment, and prosthetic rehabilitation can be safely performed in irradiated patients when properly planned and followed.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Long\u2010term preventive maintenance is essential to maintain oral health and minimize complications in head and neck cancer survivors.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cap.70066","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:03:00Z","timestamp":1778137380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidisciplinary oral rehabilitation after head and neck radiotherapy"],"prefix":"10.1002","author":[{"given":"Fernanda C. B. S.","family":"Bettero","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dentistry Anhanguera University Center of Uberl\u00e2ndia Uberl\u00e2ndia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana V. G. L. C.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Dental Materials, School of Dentistry Federal University of Uberl\u00e2ndia Uberl\u00e2ndia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L. C.","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Dental Materials, School of Dentistry Federal University of Uberl\u00e2ndia Uberl\u00e2ndia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila C. A.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, School of Dentistry University of Rio Verde (UniRV)  Rio Verde Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veridiana R.","family":"Novais","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Dental Materials, School of Dentistry Federal University of Uberl\u00e2ndia Uberl\u00e2ndia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Radioterapia","author":"Instituto Nacional de C\u00e2ncer (INCA)","year":"2023"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.oooo.2022.01.016","article-title":"Radiation therapy for head and neck cancer leads to gingival recession associated with dental caries","volume":"133","author":"Lalla RV","year":"2022","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1002\/cncr.22302","article-title":"Van den Bogaert W. Radiation\u2010induced xerostomia in patients with head and neck cancer","volume":"107","author":"Dirix P","year":"2006","journal-title":"Cancer"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/s41415-023-5864-z","article-title":"Dental management of patients irradiated for head and neck cancer","volume":"234","author":"Goh E","year":"2023","journal-title":"Br Dent J"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1007\/s00784-020-03736-0","article-title":"Effect of ionizing radiation and cariogenic biofilm challenge on root dentin caries","volume":"25","author":"Lopes CCA","year":"2021","journal-title":"Clin Oral Investig"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.1590\/1678-7757-2024-0279","article-title":"Impact of radiotherapy on chemical composition and mechanical properties of human cervical dentin","volume":"33","author":"Rodrigues RB","year":"2025","journal-title":"J Appl Oral Sci"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1007\/s00784-022-04395-z","article-title":"Chemical analysis of irradiated root dentin and its interaction with resin cements","volume":"26","author":"Pelloso AM","year":"2022","journal-title":"Clin Oral Investig"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","DOI":"10.33448\/rsd-v10i2.12745","article-title":"Impact of radiotherapy on periodontal and oral hygiene conditions","volume":"10","author":"Cartaxo AC","year":"2021","journal-title":"Res Soc Dev"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jclinepi.2017.04.026","article-title":"CARE guidelines for case reports","volume":"89","author":"Riley DS","year":"2017","journal-title":"J Clin Epidemiol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1600-051X.2011.01732.x","article-title":"Interproximal clinical attachment level to classify gingival recessions","volume":"38","author":"Cairo F","year":"2011","journal-title":"J Clin Periodontol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"35S","DOI":"10.14219\/jada.archive.2008.0353","article-title":"Measuring salivary flow","volume":"139","author":"Navazesh M","year":"2008","journal-title":"J Am Dent Assoc"},{"key":"e_1_2_9_13_1","first-page":"15","article-title":"Saliva collection methods","volume":"28","author":"Fey JMH","year":"2024","journal-title":"Mol Diagn Ther"},{"key":"e_1_2_9_14_1","first-page":"352","article-title":"Salivary analysis using different sialometry techniques","volume":"19","author":"Medeiros MG","year":"2022","journal-title":"RSBO"},{"key":"e_1_2_9_15_1","first-page":"879","article-title":"EORTC QLQ\u2010H&N35 development","volume":"33","author":"Bjordal K","year":"1994","journal-title":"Acta Oncol"},{"key":"e_1_2_9_16_1","first-page":"S305","article-title":"Mucogingival alterations","volume":"45","author":"Vignoletti F","year":"2018","journal-title":"J Clin Periodontol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/cap.10231","article-title":"Inverted T\u2010shape free gingival graft","volume":"13","author":"Alrmali A","year":"2023","journal-title":"Clin Adv Periodontics"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/cap.10264","article-title":"Expanded mesh free gingival graft","volume":"14","author":"De Greef A","year":"2024","journal-title":"Clin Adv Periodontics"},{"key":"e_1_2_9_19_1","first-page":"185","article-title":"Lasers in periodontal therapy","volume":"81","author":"Aoki A","year":"2019","journal-title":"Periodontol 2000"},{"key":"e_1_2_9_20_1","first-page":"173","article-title":"Novais VR. Oral care and fluoride in irradiated patients","volume":"136","author":"Carvalho AJD","year":"2023","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1034\/j.1601-0825.2002.1o816.x","article-title":"Saliva\u2014the defender of the oral cavity","volume":"8","author":"Amerongen AV","year":"2002","journal-title":"Oral Dis"},{"key":"e_1_2_9_22_1","first-page":"102","article-title":"Denture use and osteoradionecrosis","volume":"37","author":"Abed H","year":"2020","journal-title":"Gerodontology"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3390\/dj11030083","article-title":"Oral hygiene in head and neck cancer patients","volume":"11","author":"Lanzetti J","year":"2023","journal-title":"Dent J"},{"key":"e_1_2_9_24_1","first-page":"7","article-title":"Periodontal risk assessment","volume":"1","author":"Lang NP","year":"2003","journal-title":"Oral Health Prev Dent"},{"key":"e_1_2_9_25_1","first-page":"218","article-title":"Recall intervals and periodontal stability","volume":"46","author":"Ramseier CA","year":"2019","journal-title":"J Clin Periodontol"}],"container-title":["Clinical Advances in Periodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cap.70066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cap.70066","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cap.70066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:03:04Z","timestamp":1778137384000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1002\/cap.70066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":24,"alternative-id":["10.1002\/cap.70066"],"URL":"https:\/\/doi.org\/10.1002\/cap.70066","archive":["Portico"],"relation":{},"ISSN":["2573-8046","2163-0097"],"issn-type":[{"value":"2573-8046","type":"print"},{"value":"2163-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"assertion":[{"value":"2025-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cap.70066"}}