{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:03:05Z","timestamp":1789624985458,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aap.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Adv Periodontics"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Papillon\u2013Lef\u00e8vre syndrome (PLS) is a rare autosomal recessive disorder characterized by palmoplantar keratoderma and rapidly progressive periodontitis, resulting in early tooth loss and severe alveolar bone resorption. Prosthetic rehabilitation in such patients remains a significant clinical challenge due to compromised bone support and functional limitations. This report aims to evaluate the effectiveness of zygomatic implants as part of a multidisciplinary approach for oral rehabilitation in a patient with PLS.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A 17\u2010year\u2010old female with a confirmed diagnosis of PLS presented with partial edentulism and notable psychosocial impairment. Comprehensive clinical and radiographic evaluation informed a staged, multidisciplinary treatment approach. Phase I therapy included thorough periodontal treatment followed by extraction of hopeless teeth was performed. Rehabilitation of the severely atrophic maxilla was achieved using zygomatic implants, while conventional endosseous implants were placed in the mandible. A full\u2010arch implant\u2010supported fixed hybrid prosthesis was subsequently fabricated and delivered. The patient was maintained on a structured follow\u2010up protocol and evaluated over a 3\u2010year period, demonstrating favorable clinical outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n At the 3\u2010year follow\u2010up, the implants demonstrated excellent stability with no signs of peri\u2010implant pathology. The prosthesis provided satisfactory esthetic and functional outcomes, significantly improving masticatory efficiency and speech. The patient also exhibited marked improvement in psychological well\u2010being and quality of life.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Zygomatic implants represent a reliable and effective treatment modality for rehabilitating patients with severe maxillary atrophy associated with PLS. A multidisciplinary, patient\u2010centered approach is critical for achieving predictable long\u2010term functional, esthetic, and psychosocial outcomes in complex syndromic cases.<\/jats:p>\n <\/jats:sec>\n \n Key points<\/jats:title>\n \n \n \n Zygomatic implants can be a reliable option to restore function and esthetics when the upper jaw is severely resorbed in Papillon\u2013Lef\u00e8vre syndrome.<\/jats:p>\n <\/jats:list-item>\n \n Before considering implants in syndromic periodontitis, it is crucial to first control the periodontal condition and stick to a strict, long\u2010term maintenance plan.<\/jats:p>\n <\/jats:list-item>\n \n In young patients with complex periodontal issues, a coordinated team approach can meaningfully improve chewing, appearance, and overall confidence and quality of life.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Plain language summary<\/jats:title>\n Papillon\u2013Lef\u00e8vre syndrome is a rare inherited condition that causes severe gum disease and thickening of the skin on the hands and feet. Many patients lose their teeth at a very young age because of rapid destruction of the supporting bone around the teeth. Restoring oral function in these patients is difficult because there is often very little bone remaining in the jaws for conventional dental implants. This report describes the treatment of a 17\u2010year\u2010old female with Papillon\u2013Lef\u00e8vre syndrome using a multidisciplinary approach involving periodontal therapy, tooth extraction, zygomatic implants, conventional dental implants, and full\u2010mouth prosthetic rehabilitation. Initial treatment focused on controlling infection and stabilizing the gums before definitive rehabilitation was performed. Zygomatic implants were used in the upper jaw because of severe bone loss. The patient was followed for 3 years after treatment. The implants remained stable, and the final prosthesis improved chewing ability, speech, appearance, and psychological confidence. This case demonstrates that careful planning, strict maintenance, and a multidisciplinary approach can achieve successful long\u2010term rehabilitation in patients with severe syndromic periodontal destruction.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cap.70094","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:21:47Z","timestamp":1789622507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidisciplinary rehabilitation of Papillon\u2013Lef\u00e8vre syndrome using zygomatic implants: A 3\u2010year case report"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3343-1902","authenticated-orcid":false,"given":"Subasree","family":"S","sequence":"first","affiliation":[{"name":"Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science Saveetha University Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaarthikeyan","family":"G","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science Saveetha University Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0021-4044","authenticated-orcid":false,"given":"Maria Sharon","family":"V","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science Saveetha University Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4103\/jid.jid_67_20","article-title":"Nonsurgical periodontal management of Papillon\u2013Lefevre syndrome","volume":"11","author":"Guruprasad CN","year":"2021","journal-title":"J Interdiscip Dentistry"},{"issue":"4","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.4103\/jomfp.jomfp_25_24","article-title":"Papillon\u2013Lefevre syndrome: case series","volume":"28","author":"Patel VI","year":"2024","journal-title":"J Oral Maxillofac Pathol"},{"issue":"4","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4274\/tjd.galenos.2024.00719","article-title":"Papillon\u2013Lef\u00e8vre syndrome: a report of four cases and a brief review of the literature","volume":"18","author":"Edek YC","year":"2024","journal-title":"Turk J 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patients by dental implants: a systematic review","volume":"46","author":"Atarbashi\u2010Moghadam F","year":"2020","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"issue":"2","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.prosdent.2024.10.007","article-title":"Computer\u2010aided prosthetic rehabilitation of a resected maxilla after mucormycosis using a quad zygomatic implant protocol with digital planning","volume":"133","author":"Koppaka R","year":"2025","journal-title":"J Prosthet Dent"},{"issue":"2","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","DOI":"10.1615\/JLongTermEffMedImplants.2025052691","article-title":"Inflammatory and antioxidant status in peri\u2010implant health and diseases: a biochemical analysis","volume":"35","author":"Chakraborty P","year":"2025","journal-title":"J Long Term Eff Med Implants"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.04.026"}],"container-title":["Clinical Advances in 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