{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:15:16Z","timestamp":1790838916138,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T00:00:00Z","timestamp":1101254400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two novel labdane\u2010type diterpenoids, butanedioic acid mono[(13<jats:italic>S<\/jats:italic>)\u201013\u2010hydroxylabda\u20108(17),14\u2010dien\u201019\u2010yl] ester (<jats:bold>1<\/jats:bold>) and butanedioic acid bis[(13<jats:italic>S<\/jats:italic>)\u201013\u2010hydroxylabda\u20108(17),14\u2010dien\u201019\u2010yl] ester (<jats:bold>2<\/jats:bold>), along with the eleven known diterpenoids <jats:bold>3<\/jats:bold>\u2013<jats:bold>13<\/jats:bold> and three other known compounds, were isolated from the bark of <jats:italic>Larix chinensis.<\/jats:italic> Their structures were elucidated both spectroscopically and chemically. The major diterpenoids <jats:bold>1<\/jats:bold>\u2013<jats:bold>9, 11<\/jats:bold>, and <jats:bold>13<\/jats:bold>, as well as the very abundant phenolic compound <jats:bold>16<\/jats:bold>, were subjected to antibacterial and cytotoxic bioassays. Compounds <jats:bold>7<\/jats:bold> and <jats:bold>9<\/jats:bold> showed remarkable <jats:italic>in vitro<\/jats:italic> inhibition of <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>S.\u2005epidermidis<\/jats:italic> (<jats:italic>MIC<\/jats:italic>=37\u201373\u2005\u03bc<jats:sc>M<\/jats:sc>).<\/jats:p>","DOI":"10.1002\/cbdv.200490128","type":"journal-article","created":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T16:35:51Z","timestamp":1101314151000},"page":"1702-1707","source":"Crossref","is-referenced-by-count":21,"title":["Novel Antibacterial Diterpenoids from <i>Larix chinensis<\/i> B<scp>eissn<\/scp>"],"prefix":"10.1002","volume":"1","author":[{"given":"Jun\u2010Juan","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Qi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Ping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Min","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,24]]},"reference":[{"key":"e_1_2_1_1_2","first-page":"832","volume-title":"\u2018Dictionary of Chinese Traditional Medicines\u2019","author":"College Jiangsu New Medical","year":"1986"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960843"},{"key":"e_1_2_1_2_3","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-10873"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1071\/CH9732735"},{"key":"e_1_2_1_3_3","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)89538-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199611)10:7<604::AID-PTR922>3.0.CO;2-C"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1071\/CH9730209"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.36.3967"},{"key":"e_1_2_1_7_2","first-page":"568","volume":"73","author":"Barrero J. 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Pharmacol."}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbdv.200490128","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.200490128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T04:04:30Z","timestamp":1697601870000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.200490128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1002\/cbdv.200490128"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.200490128","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}