{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:49:17Z","timestamp":1792154957942,"version":"4.4.0"},"reference-count":65,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3714,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["C&amp;B"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1002\/cbdv.200590064","type":"journal-article","created":{"date-parts":[[2005,7,18]],"date-time":"2005-07-18T13:17:31Z","timestamp":1121692651000},"page":"872-885","source":"Crossref","is-referenced-by-count":64,"title":["Predicting Drug Metabolism - An Evaluation of the Expert SystemMETEOR"],"prefix":"10.1002","volume":"2","author":[{"given":"Bernard","family":"Testa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Loyse","family":"Balmat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Judson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"10.1002\/cbdv.200590064-BIB1","unstructured":"\u2018Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies\u2019, Eds. B. Testa, H. van de Waterbeemd, G. Folkers, R. Guy, Verlag Helvetica Chimica Acta, Z\u00fcrich, Wiley-VCH, Weinheim, 2001."},{"key":"10.1002\/cbdv.200590064-BIB2","author":"Testa","unstructured":", , in \u2018Burger's Medicinal Chemistry and Drug Discovery\u2019, 6th edn., Ed. D.\u2005J. Abraham, Wiley-Interscience, Hoboken, 2003, Vol.\u20052, p.\u2005431-498."},{"key":"10.1002\/cbdv.200590064-BIB3","author":"Testa","unstructured":", \u2018The Metabolism of Drugs and Other Xenobiotics - Biochemistry of Redox Reactions\u2019, Academic Press, London, 1995."},{"key":"10.1002\/cbdv.200590064-BIB4","author":"Testa","unstructured":", , \u2018 Hydrolysis in Drug and Prodrug Metabolism - Chemistry, Biochemistry, and Enzymology\u2019, Verlag Helvetica Chimica Acta, Z\u00fcrich, Wiley-VCH, Weinheim, 2003."},{"key":"10.1002\/cbdv.200590064-BIB5A","first-page":"17","volume":"May","author":"Henderson","year":"2004","journal-title":"Curr. Drug Discov."},{"key":"10.1002\/cbdv.200590064-BIB5B","first-page":"49","volume":"7","author":"Penzotti","year":"2004","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"10.1002\/cbdv.200590064-BIB5C","first-page":"123","volume":"6","author":"Wilson","year":"2003","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"10.1002\/cbdv.200590064-BIB5D","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nrd1032","volume":"2","author":"Waterbeemd","year":"2003","journal-title":"Nature Rev. Drug Discov."},{"key":"10.1002\/cbdv.200590064-BIB5E","first-page":"104","volume":"5","author":"Williams","year":"2002","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"10.1002\/cbdv.200590064-BIB5F","first-page":"33","volume":"5","author":"Waterbeemd","year":"2002","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"10.1002\/cbdv.200590064-BIB5G","first-page":"357","volume":"6","author":"Li","year":"2001","journal-title":"Drug Des. Technol."},{"key":"10.1002\/cbdv.200590064-BIB5H","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/med.1017","volume":"21","author":"Thompson","year":"2001","journal-title":"Med. Res. Rev."},{"key":"10.1002\/cbdv.200590064-BIB5I","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/(SICI)1098-1128(199605)16:3<243::AID-MED2>3.0.CO;2-Z","volume":"16","author":"Smith","year":"1996","journal-title":"Med. Res. Rev."},{"key":"10.1002\/cbdv.200590064-BIB6","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1351\/pac200476050907","volume":"76","author":"Testa","year":"2004","journal-title":"Pure Appl. Chem."},{"key":"10.1002\/cbdv.200590064-BIB7.1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1081\/DMR-120028428","volume":"36","author":"Hansch","year":"2004","journal-title":"Drug Metab. Rev."},{"key":"10.1002\/cbdv.200590064-BIB7.2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1023\/A:1008741731244","volume":"19","author":"Testa","year":"2000","journal-title":"Perspect. Drug Discov. Des."},{"key":"10.1002\/cbdv.200590064-BIB7.3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3109\/03602539709037593","volume":"29","author":"Lewis","year":"1997","journal-title":"Drug Metab. Rev."},{"key":"10.1002\/cbdv.200590064-BIB8","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1021\/jm030102a","volume":"46","author":"Korolev","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1002\/cbdv.200590064-BIB9.1","first-page":"43","volume":"7","author":"Harris","year":"2004","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"10.1002\/cbdv.200590064-BIB9.2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1124\/dmd.30.1.7","volume":"30","author":"Jones","year":"2002","journal-title":"Drug Metab. Disposit."},{"key":"10.1002\/cbdv.200590064-BIB9.3","first-page":"623","volume":"29","author":"Hines","year":"2001","journal-title":"Drug Metab. Disposit."},{"key":"10.1002\/cbdv.200590064-BIB9.4","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/004982599238380","volume":"29","author":"Segall","year":"1999","journal-title":"Xenobiotica"},{"key":"10.1002\/cbdv.200590064-BIB9.5","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1081\/DMR-100101943","volume":"31","author":"Lewis","year":"1999","journal-title":"Drug Metab. Rev."},{"key":"10.1002\/cbdv.200590064-BIB10.1","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1021\/jm020397c","volume":"46","author":"Smith","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1002\/cbdv.200590064-BIB10.2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0165-6147(03)00049-X","volume":"24","author":"Ekins","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1002\/cbdv.200590064-BIB10.3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1023\/A:1008102217770","volume":"15","author":"Poso","year":"2001","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"10.1002\/cbdv.200590064-BIB10.4","first-page":"463","volume":"295","author":"Ekins","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1002\/cbdv.200590064-BIB10.5","first-page":"424","volume":"291","author":"Ekins","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1002\/cbdv.200590064-BIB11.1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1021\/jm030972s","volume":"47","author":"Afzelius","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1002\/cbdv.200590064-BIB11.2","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1021\/jm021104i","volume":"46","author":"Zamora","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1002\/cbdv.200590064-BIB12.1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1124\/mol.65.2.301","volume":"65","author":"Sorich","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1002\/cbdv.200590064-BIB12.2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1021\/jm0209578","volume":"43","author":"Venhorst","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1002\/cbdv.200590064-BIB12.3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/00498250110112015","volume":"32","author":"Lewis","year":"2002","journal-title":"Xenobiotica"},{"key":"10.1002\/cbdv.200590064-BIB12.4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1081\/DMR-120001390","volume":"34","author":"Lewis","year":"2002","journal-title":"Drug Metab. Rev."},{"key":"10.1002\/cbdv.200590064-BIB12.5","author":"Laak","unstructured":"in \u2018Pharmacokinetic Optimization in Drug Research - Biological, Physicochemical and Computational Strategies\u2019, Eds. B. Testa, H. van de Waterbeemd, G. Folkers, R. Guy, Verlag Helvetica Chimica Acta, Zurich, Wiley-VCH, Weinheim, 2001, p.\u2005551-588;"},{"key":"10.1002\/cbdv.200590064-BIB12.6","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1080\/004982599238227","volume":"29","author":"Lewis","year":"1999","journal-title":"Xenobiotica"},{"key":"10.1002\/cbdv.200590064-BIB12.7","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1124\/mol.56.2.272","volume":"56","author":"Chen","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1002\/cbdv.200590064-BIB12.8","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3109\/03602539709037596","volume":"29","author":"Groot","year":"1997","journal-title":"Drug Metab. Rev."},{"key":"10.1002\/cbdv.200590064-BIB13.1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1126\/science.1099736","volume":"305","author":"Williams","year":"2004","journal-title":"Science"},{"key":"10.1002\/cbdv.200590064-BIB13.2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nature01862","volume":"424","author":"Williams","year":"2003","journal-title":"Nature"},{"key":"10.1002\/cbdv.200590064-BIB13.3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1097-2765(00)80408-6","volume":"5","author":"Williams","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1002\/cbdv.200590064-BIB14.1","author":"Cruciani","unstructured":", , , in \u2018Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies\u2019, Eds. B. Testa, S. Kraemer, H. Wunderli-Allenspach, G. Folkers, Verlag Helvetica Chimica Acta, Zurich, Wiley-VCH, Weinheim, 2005, in press;"},{"key":"10.1002\/cbdv.200590064-BIB14.2","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1021\/jm0110791","volume":"45","author":"Groot","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1002\/cbdv.200590064-BIB14C","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.1021\/jm991058v","volume":"42","author":"Groot","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1002\/cbdv.200590064-BIB15","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S1359-6446(99)01401-4","volume":"4","author":"Hawkins","year":"1999","journal-title":"Drug Discov. Today"},{"key":"10.1002\/cbdv.200590064-BIB16","unstructured":"\u2018Metabolism Databases and High-Throughput Testing During Drug Design and Development\u2019, Ed. P.\u2005W. Erhardt, Blackwell Science, London, 1999."},{"key":"10.1002\/cbdv.200590064-BIB17","unstructured":"http:\/\/www.mdl.com"},{"key":"10.1002\/cbdv.200590064-BIB18","doi-asserted-by":"crossref","unstructured":"\u2018Biotransformations: A Survey of the Biotransformations of Drugs and Chemicals in Animals\u2019, Ed. D.\u2005R. Hawkins, The Royal Society of Chemistry, London, Vol.\u20051-7, 1988-1996.","DOI":"10.1039\/9781847550279"},{"key":"10.1002\/cbdv.200590064-BIB19","unstructured":"http:\/\/www.accelrys.com"},{"key":"10.1002\/cbdv.200590064-BIB20","unstructured":"http:\/\/www.compudrug.com"},{"key":"10.1002\/cbdv.200590064-BIB21","unstructured":"http:\/\/www.multicase.com"},{"key":"10.1002\/cbdv.200590064-BIB22","unstructured":"http:\/\/www.lhasalimited.org"},{"key":"10.1002\/cbdv.200590064-BIB23A","volume-title":"\u2018Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies\u2019","author":"Judson","year":"2005","unstructured":", in \u2018Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies\u2019, Eds. , Verlag Helvetica Chimica Acta, Zurich, Wiley-VCH, Weinheim, 2005, in press;"},{"key":"10.1002\/cbdv.200590064-BIB23B","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1021\/ci020271o","volume":"43","author":"Judson","year":"2003","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1002\/cbdv.200590064-BIB23C","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1021\/ci020272g","volume":"43","author":"Judson","year":"2003","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1002\/cbdv.200590064-BIB23D","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1021\/ci0202739","volume":"43","author":"Button","year":"2003","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1002\/cbdv.200590064-BIB23E","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0169-409X(02)00011-X","volume":"54","author":"Langowski","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1002\/cbdv.200590064-BIB23F","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1021\/ci960094p","volume":"37","author":"Tonnelier","year":"1997","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1002\/cbdv.200590064-BIB23G","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1021\/ci9500905","volume":"36","author":"Judson","year":"1996","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1002\/cbdv.200590064-BIB24","unstructured":"http:\/\/www.daylight.com"},{"key":"10.1002\/cbdv.200590064-BIB25","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1124\/dmd.30.5.553","volume":"30","author":"Mannens","year":"2002","journal-title":"Drug Metab. Disp."},{"key":"10.1002\/cbdv.200590064-BIB26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/00498250110113230","volume":"32","author":"Wu","year":"2002","journal-title":"Xenobiotica"},{"key":"10.1002\/cbdv.200590064-BIB27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1124\/dmd.31.1.67","volume":"31","author":"Iyer","year":"2003","journal-title":"Drug Metab. Disp."},{"key":"10.1002\/cbdv.200590064-BIB28","first-page":"266","volume":"23","author":"Balani","year":"1995","journal-title":"Drug Metab. Disp."},{"key":"10.1002\/cbdv.200590064-BIB29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0169-409X(99)00018-6","volume":"39","author":"Lin","year":"1999","journal-title":"Adv. Drug Deliv. Rev."}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbdv.200590064","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/cbdv.200590064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T00:08:36Z","timestamp":1625270916000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.200590064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":65,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,7]]}},"URL":"https:\/\/doi.org\/10.1002\/cbdv.200590064","relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}