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The reaction consists in an aldolization\u2010type C,C\u2010bond formation, accompanied by a (presumably aldehyde\u2010catalyzed) hydration of one of the two nitrile groups and the formation of two cyclic aminal\u2010type groupings, each of the latter incorporating an additional molecule of the aldehyde. Should this so far unexplored type of chemistry of the HCN\u2010tetramer prove to have some generality, the finding might add a new dimension to the potential etiological relevance of this HCN\u2010oligomer.<\/jats:p>","DOI":"10.1002\/cbdv.200790049","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T11:46:49Z","timestamp":1176983209000},"page":"541-553","source":"Crossref","is-referenced-by-count":18,"title":["Reactions of the HCN\u2010Tetramer with Aldehydes"],"prefix":"10.1002","volume":"4","author":[{"given":"Klemens","family":"Koch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.\u2005Bernd","family":"Schweizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Eschenmoser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,19]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200603209"},{"key":"e_1_2_1_2_2","unstructured":"K. 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