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In this context, the robustness postulate of classical prebiotic chemistry is questioned, and, by an analysis of the (hypothetical) reaction\u2010tree of a stepwise hydrolysis of the HCN\u2010tetramer, it is shown how such a non\u2010robust chemical reaction platform could harbor the potential for the emergence of autocatalytic cycles. It is concluded that the chemistry of HCN should be revisited by focussing on its non\u2010robust parts in order to demonstrate its full potential as one of the possible roots of prebiotic self\u2010organizing chemical processes.<\/jats:p>","DOI":"10.1002\/cbdv.200790050","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T11:47:03Z","timestamp":1176983223000},"page":"554-573","source":"Crossref","is-referenced-by-count":99,"title":["On a Hypothetical Generational Relationship between HCN and Constituents of the Reductive Citric Acid Cycle"],"prefix":"10.1002","volume":"4","author":[{"given":"Albert","family":"Eschenmoser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,19]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200790049"},{"key":"e_1_2_1_2_2","unstructured":"C.\u2005A. 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