{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:28:08Z","timestamp":1791142088929,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,9,21]],"date-time":"2007-09-21T00:00:00Z","timestamp":1190332800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An amphiphilic <jats:italic>\u03b1<\/jats:italic>\u2010phenyl\u2010<jats:italic>N\u2010<\/jats:italic>(<jats:italic>tert<\/jats:italic>\u2010butyl) nitrone (PBN) derivative, <jats:italic>N<\/jats:italic>\u2010{[4\u2010(lactobionamido)methyl]benzylidene}\u20101,1\u2010dimethyl\u20102\u2010(octylsulfanyl)ethylamine <jats:italic>N<\/jats:italic>\u2010oxide (LPBNSH), newly synthesized from its original form PBN in hopes of clinical use, was intraperitoneally administered to <jats:italic>Long\u2013Evans<\/jats:italic> Cinnamon (LEC) rats every 2 days at the concentrations of 0.1, 0.5, 1.0, and 2.0\u2005mg\/kg. We found that LPBNSH protected against copper\u2010induced hepatitis with jaundice in LEC rats at concentrations of 0.1 and 0.5\u2005mg\/kg, which were extremely low compared with that of PBN. It also effectively prevented the loss of body weight, reduced the death rate, and suppressed the increase in serum aspartate aminotransferase and alanine aminotransferase values arising from fulminant hepatitis with jaundice at the same concentrations. Similar results were observed when PBN was administered at the concentration of 150\u2005mg\/kg. Immunohistochemical analysis of 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine and measurement of thiobarbituric acid\u2010reactive substances in the liver showed that LPBNSH largely suppressed the formation of these oxidative products at same concentrations. No difference in the abnormal accumulation of copper in the liver between the LPBNSH administered and control groups was observed. From these results, it was concluded that LPBNSH exhibited liver\u2010protective effects against fulminant hepatitis with jaundice at <jats:italic>ca.<\/jats:italic> 1\/1000, 500 the molar concentration of PBN and, therefore, was clinically promising.<\/jats:p>","DOI":"10.1002\/cbdv.200790184","type":"journal-article","created":{"date-parts":[[2007,9,21]],"date-time":"2007-09-21T18:29:11Z","timestamp":1190399351000},"page":"2253-2267","source":"Crossref","is-referenced-by-count":14,"title":["A New Amphiphilic Derivative, <i>N<\/i>\u2010{[4\u2010(Lactobionamido)methyl]benzylidene}\u2010 1,1\u2010dimethyl\u20102\u2010(octylsulfanyl)ethylamine <i>N<\/i>\u2010Oxide, Has a Protective Effect Against Copper\u2010Induced Fulminant Hepatitis in <i>Long\u2013Evans<\/i> Cinnamon Rats at an Extremely Low Concentration Compared with Its Original Form <i>\u03b1<\/i>\u2010Phenyl\u2010<i>N<\/i>\u2010(<i>tert<\/i>\u2010butyl) Nitrone"],"prefix":"10.1002","volume":"4","author":[{"given":"Taketoshi","family":"Asanuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Inanami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Waki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Iizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketo","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Durand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ange","family":"Polidori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Pucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikinori","family":"Kuwabara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,21]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar50037a005"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86101-Z"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb02103.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(93)90150-S"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.9.3633"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200203000-00009"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(96)00222-5"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(97)00139-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00663-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)00844-2"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101403200"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm030873e"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2003.07.003"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.1.190"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm991154w"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo982343"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68031173.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(03)00545-6"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(02)01079-X"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03425.x"},{"key":"e_1_2_1_21_2","unstructured":"Y. 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