{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:43:22Z","timestamp":1768812202109,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,3,24]],"date-time":"2009-03-24T00:00:00Z","timestamp":1237852800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/gif\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mcontent.gif\"><jats:alt-text>magnified image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><jats:p>Pro\u2010 and anti\u2010oxidative effects of an anti\u2010rheumatoid drug, <jats:sc>D<\/jats:sc>\u2010penicillamine (<jats:sc>D<\/jats:sc>\u2010PN), on the kinetics of high\u2010molar\u2010mass hyaluronan (HA) degradation were monitored using the method of\u2005rotational viscometry. The degradation of the dissolved HA macromolecules was attained by applying the <jats:italic>Weissberger<\/jats:italic>'s system comprising ascorbic acid <jats:italic>plus<\/jats:italic> cupric ions. Electron paramagnetic resonance (EPR) spectroscopy was used to identify the generated free radicals. The results obtained indicate that the initial anti\u2010oxidative action of <jats:sc>D<\/jats:sc>\u2010PN is followed by induction of pro\u2010oxidative conditions due to the generation of reactive free radicals. It is speculated, however, that the latter situation may be considered as an advantageous property of <jats:sc>D<\/jats:sc>\u2010PN. Hydroxyl radicals formed in this way may participate in decomposition of proteinases, which are believed to be responsible for the destruction of joint cartilage under rheumatoid arthritic conditions.<\/jats:p>","DOI":"10.1002\/cbdv.200800261","type":"journal-article","created":{"date-parts":[[2009,3,24]],"date-time":"2009-03-24T13:30:52Z","timestamp":1237901452000},"page":"389-395","source":"Crossref","is-referenced-by-count":12,"title":["Degradation of High\u2010Molar\u2010Mass Hyaluronan by Ascorbate <i>plus<\/i> Cupric Ions: Effects of <scp>D<\/scp>\u2010Penicillamine Addition"],"prefix":"10.1002","volume":"6","author":[{"given":"Katar\u00edna","family":"Valachov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Rapta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigorij","family":"Kogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Hrab\u00e1rov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Gemeiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ladislav","family":"\u0160olt\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,24]]},"reference":[{"key":"e_1_2_1_1_2","unstructured":"B.\u2005J. 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