{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:50:09Z","timestamp":1774936209227,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Forty\u2010three 2\u2010[(benzotriazol\u20101\/2\u2010yl)methyl]benzimidazoles, bearing either linear (dialkylamino)alkyl\u2010 or bulkier (quinolizidin\u20101\u2010yl)alkyl moieties at position 1, were evaluated in cell\u2010based assays for cytotoxicity and antiviral activity against viruses representative of two of the three genera of the Flaviviridae family, <jats:italic>i.e. Flaviviruses<\/jats:italic> (Yellow Fever Virus (YFV)) and <jats:italic>Pestiviruses<\/jats:italic> (Bovine Viral Diarrhoea Virus (BVDV)), as <jats:italic>Hepaciviruses<\/jats:italic> can hardly be used in routine cell\u2010based assays. Compounds were also tested against representatives of other virus families. Among ssRNA<jats:sup>+<\/jats:sup> viruses were a retrovirus (Human Immunodeficiency Virus type 1 (HIV\u20101)), two picornaviruses (Coxsackie Virus type B2 (CVB2), and Poliovirus type\u20101, Sabin strain (Sb\u20101)); among ssRNA<jats:sup>\u2212<\/jats:sup> viruses were a <jats:italic>Paramyxoviridae<\/jats:italic> (Respiratory Syncytial Virus (RSV)) and a <jats:italic>Rhabdoviridae<\/jats:italic> (Vesicular Stomatitis Virus (VSV)) representative. Among double\u2010stranded RNA (dsRNA) viruses was a <jats:italic>Reoviridae<\/jats:italic> representative (Reo\u20101). Two representatives of DNA virus families were also included: <jats:italic>Herpes Simplex<\/jats:italic> type 1, (HSV\u20101; Herpesviridae) and Vaccinia Virus (VV; Poxviridae). Most compounds exhibited potent activity against RSV, with <jats:italic>EC<\/jats:italic><jats:sub>50<\/jats:sub> values as low as 20\u2005n<jats:sc>M<\/jats:sc>. Moreover, some compounds, in particular when bearing a (quinolizidin\u20101\u2010yl)alkyl residue, were also moderately active against BVDV, YFV, and CVB2.<\/jats:p>","DOI":"10.1002\/cbdv.200890203","type":"journal-article","created":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T07:19:04Z","timestamp":1227683944000},"page":"2386-2401","source":"Crossref","is-referenced-by-count":75,"title":["Antiviral Activity of Benzimidazole Derivatives. I. 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