{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:17:54Z","timestamp":1789363074006,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,9,22]],"date-time":"2009-09-22T00:00:00Z","timestamp":1253577600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>MCM\u201041, a mesoporous silica nanomaterial with a high surface area for adsorption of small molecules, is a potential new type of delivery vehicle for therapeutic and diagnostic agents. In this report, we show that MCM\u201041 adsorbs the front\u2010line anticancer drug carboplatin, [Pt(CBDCA\u2010<jats:italic>O<\/jats:italic>,<jats:italic>O\u2032<\/jats:italic>)(NH<jats:sub>3<\/jats:sub>)<jats:sub>2<\/jats:sub>] (CBDCA=cyclobutane\u20101,1\u2010dicarboxylate; <jats:bold>1<\/jats:bold>), which is used to treat ovarian, lung, and other types of cancer. UV\/Visible difference absorption spectroscopy shows that MCM\u201041 adsorbs 1.8\u00b10.2% of its own weight of carboplatin after a 24\u2005h exposure to 26.9\u2005m<jats:sc>M<\/jats:sc> drug in H<jats:sub>2<\/jats:sub>O. The <jats:italic>pseudo<\/jats:italic>\u2010first\u2010order rate constant for adsorption of carboplatin by MCM\u201041, measured using [<jats:sup>1<\/jats:sup>H,<jats:sup>15<\/jats:sup>N] heteronuclear single quantum coherence (HSQC) NMR, and <jats:sup>15<\/jats:sup>N\u2010labeled carboplatin is <jats:italic>k<\/jats:italic><jats:sub>1<\/jats:sub>=2.92\u00b12.17\u00d710<jats:sup>\u22126<\/jats:sup>\u2005s<jats:sup>\u22121<\/jats:sup> at <jats:italic>ca.<\/jats:italic> 25\u00b0.<\/jats:p>","DOI":"10.1002\/cbdv.200900021","type":"journal-article","created":{"date-parts":[[2009,9,22]],"date-time":"2009-09-22T17:54:54Z","timestamp":1253642094000},"page":"1343-1349","source":"Crossref","is-referenced-by-count":32,"title":["Adsorption of the Pt<sup>II<\/sup> Anticancer Drug Carboplatin by Mesoporous Silica"],"prefix":"10.1002","volume":"6","author":[{"given":"Anthony\u2005J.","family":"Di\u2005Pasqua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Wallner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah\u2005J.","family":"Kerwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James\u2005C.","family":"Dabrowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,9,22]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00053a020"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/359710a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200600226"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200604488"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/cm0011559"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2003.12.007"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.05.006"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.materresbull.2005.02.011"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jssc.2006.02.004"},{"key":"e_1_2_1_10_2","first-page":"1663","volume":"10","author":"Boulikas T.","year":"2003","journal-title":"Oncol. 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