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We investigated the polarized transport in the mucosal\u2010to\u2010serosal direction of monocarboxylic acid\u2010type drugs through the excised rat jejunal tissue and an artificial membrane. We established that,<jats:italic>in vitro<\/jats:italic>, these substances are most probably not transported by monocarboxylate transporter 1, but by passive pH\u2010dependent transport. We also studied various influences on the permeability of fluorescein, a low permeability marker, through isolated rat intestinal segments, Caco\u20102 cell monolayers, and an artificial membrane. Polarized transport of fluorescein in the serosal\u2010to\u2010mucosal direction through the rat jejunum by multidrug resistance\u2010associated protein was triggered by the addition of<jats:sc>D<\/jats:sc>\u2010glucose to the mucosal side, while the pH\u2010dependent increase of fluorescein influx is presumably the consequence of a monocarboxylate transporter and a member of the organic\u2010anion transporting polypeptide family. With permeability experiments through the excised segments of rat small intestine, we ascertained that ciprofloxacin is a low\u2010permeability drug and has higher and pH\u2010dependent transport in the mucosal\u2010to\u2010serosal direction than in the opposite direction. We also established that neither the permeability of fluoroquinolones nor their solubility in different buffers was influenced by the interactions with metal cations.<\/jats:p>","DOI":"10.1002\/cbdv.200900076","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T06:32:38Z","timestamp":1259044358000},"page":"1923-1932","source":"Crossref","is-referenced-by-count":11,"title":["Membrane Permeability in the Gastrointestinal Tract: The Interplay between Microclimate pH and Transporters"],"prefix":"10.1002","volume":"6","author":[{"given":"Albin","family":"Kristl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,11,24]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016086003070"},{"key":"e_1_2_1_1_3","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2005.029959"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1957.tb12289.x"},{"key":"e_1_2_1_2_3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0022-3565(25)11878-8","volume":"119","author":"Shore P. 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