{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T08:09:15Z","timestamp":1784016555949,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T00:00:00Z","timestamp":1271289600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Four phenolic acids, namely 2\u2010[(<jats:italic>Z<\/jats:italic>)\u2010heptadec\u201011\u2010enyl]\u20106\u2010hydroxybenzoic acid (<jats:bold>1<\/jats:bold>), 2\u2010[(6<jats:italic>Z<\/jats:italic>,9<jats:italic>Z<\/jats:italic>,12<jats:italic>Z<\/jats:italic>)\u2010heptadeca\u20106,9,12\u2010trienyl]\u20106\u2010hydroxybenzoic acid (<jats:bold>2<\/jats:bold>), 2\u2010[(9<jats:italic>Z<\/jats:italic>,12<jats:italic>Z<\/jats:italic>)\u2010heptadeca\u20109,12\u2010dienyl]<jats:italic>\u2010<\/jats:italic>6<jats:italic>\u2010<\/jats:italic>hydroxybenzoic acid (<jats:bold>3<\/jats:bold>), and 2\u2010hydroxy\u20106\u2010(12\u2010phenyldodecyl)benzoic acid (<jats:bold>4<\/jats:bold>), and one sesquiterpene, asperpenoid (<jats:bold>5<\/jats:bold>), were isolated from the 95% EtOH extract of the roots of <jats:italic>Homalomena occulta<\/jats:italic>, among which <jats:bold>1, 2<\/jats:bold>, and <jats:bold>5<\/jats:bold> represent new compounds. Further, the phenolic acids <jats:bold>1<\/jats:bold>\u2013<jats:bold>4<\/jats:bold> exhibited BACE1 (<jats:italic>\u03b2<\/jats:italic>\u2010secretase) inhibitory activity with <jats:italic>IC<\/jats:italic><jats:sub>50<\/jats:sub> values of 6.23\u00b10.94, 6.28\u00b10.63, 7.93\u00b10.38, and 7.65\u00b10.62\u2005\u03bc<jats:sc>M<\/jats:sc>, respectively.<\/jats:p>","DOI":"10.1002\/cbdv.200900280","type":"journal-article","created":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T19:29:21Z","timestamp":1271359761000},"page":"984-992","source":"Crossref","is-referenced-by-count":18,"title":["BACE1 (Beta\u2010Secretase) Inhibitory Phenolic Acids and a Novel Sesquiterpenoid from <i>Homalomena occulta<\/i>"],"prefix":"10.1002","volume":"7","author":[{"given":"Xiao\u2010Yan","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Shan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Shuo","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,4,15]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(84)80190-4"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2003.12.004"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.130039"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm030247h"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161205774370825"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.09.018"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-815491"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02977896"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02977345"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2006.09.003"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-001-1139-9"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.05.093"},{"key":"e_1_2_1_13_2","first-page":"1000","volume":"41","author":"Gao B.","year":"2006","journal-title":"Acta Pharm. 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