{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:56:11Z","timestamp":1780052171005,"version":"3.53.1"},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,6,16]],"date-time":"2010-06-16T00:00:00Z","timestamp":1276646400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Racemization of aspartyl (Asp) residues in peptides and proteins has been considered to be a nonenzymatic chemical reaction which occurs <jats:italic>via<\/jats:italic> succinimide formation. However, it has not been known yet what conditions in living body accelerate the inversion of the <jats:sc>L<\/jats:sc>\u2010 to the <jats:sc>D<\/jats:sc>\u2010form. Here, we examined the effect of ultraviolet (UV) exposure or oxidative stress on the formation of <jats:sc>D<\/jats:sc>\u2010Asp residues in the elastin mimic peptides with or without heat treatment. As a result, UV exposure did not affect the <jats:sc>D<\/jats:sc>\u2010Asp formation in peptides. On the other hand, the amount of <jats:sc>D<\/jats:sc>\u2010Asp in heat\u2010treated peptide solution at the same time as addition of HO<jats:sup>.<\/jats:sup> radical, H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, and lipid peroxide was significantly increased. These results indicate that the inversion rate to <jats:sc>D<\/jats:sc>\u2010form of Asp residues in skin elastin is accelerated by generation of reactive oxygen species (ROS), and that oxidative stress might be closely related to <jats:sc>D<\/jats:sc>\u2010Asp formation in aging proteins.<\/jats:p>","DOI":"10.1002\/cbdv.200900348","type":"journal-article","created":{"date-parts":[[2010,6,18]],"date-time":"2010-06-18T16:45:53Z","timestamp":1276879553000},"page":"1408-1412","source":"Crossref","is-referenced-by-count":19,"title":["Oxidative Stress Induces the Formation of <scp>D<\/scp>\u2010Aspartyl Residues in the Elastin Mimic Peptides"],"prefix":"10.1002","volume":"7","author":[{"given":"Katsunori","family":"Kuge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Nakaoji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,16]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02405005"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(94)90003-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(92)90132-Z"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(87)90797-2"},{"key":"e_1_2_1_5_2","first-page":"141","volume":"62","author":"Ohtani S.","year":"1998","journal-title":"Growth Dev. 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