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The differential QSAR approach reported in this study can be used in protocols for the development of drugs to combat drug\u2010resistant pathogens arising continuously in nature due to mutations. The pairwise kappa values in conjunction with appropriate drug targets and their corresponding set of ligands may be a useful tool in gauging the evolving mutual similarities and dissimilarities of pathogenic organisms from purely computed mathematical descriptors of the ligands.<\/jats:p>","DOI":"10.1002\/cbdv.201000111","type":"journal-article","created":{"date-parts":[[2011,3,14]],"date-time":"2011-03-14T11:52:30Z","timestamp":1300103550000},"page":"440-453","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of Dihydrofolate Reductases from Multiple Strains of <i>Plasmodium falciparum<\/i> Using Mathematical Descriptors of Their Inhibitors"],"prefix":"10.1002","volume":"8","author":[{"given":"Subhash C.","family":"Basak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas M.","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,14]]},"reference":[{"key":"e_1_2_1_1_2","unstructured":"World Health Organization (WHO) \u2018World Malaria Report (https:\/\/apps.who.int\/malaria\/wmr2008\/malaria2008.pdf)\u2019 Geneva 2008."},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.08.020"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.20353"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.20344"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.20343"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01525-8"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.8.3018"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1128\/AAC.42.1.164","volume":"42","author":"Nzila\u2010Mounda A.","year":"1998","journal-title":"Antimicrob. 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