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They exhibit square\u2010planar geometry with CuN\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    coordination, where the dianionic\n                    <jats:italic>Schiff<\/jats:italic>\n                    base acts as a tetradentate N\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    donor ligand. Calf thymus (CT)\u2010DNA Binding studies revealed that the complexes possess good binding propensities (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>b<\/jats:sub>\n                    =3.13\u00d710\n                    <jats:sup>5<\/jats:sup>\n                    for\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>b<\/jats:sub>\n                    =2.99\u00d710\n                    <jats:sup>5<\/jats:sup>\n                    \u2005\n                    <jats:sc>M<\/jats:sc>\n                    <jats:sup>\u22121<\/jats:sup>\n                    for\n                    <jats:bold>2<\/jats:bold>\n                    ). They show good DNA\u2010cleavage abilities under oxidative and hydrolytic conditions. Complex\n                    <jats:bold>1<\/jats:bold>\n                    binds and cleaves DNA more efficiently as compared to\n                    <jats:bold>2<\/jats:bold>\n                    due to the presence of an extended aromatic phenyl ring which might be involved in an additional stacking interaction with DNA bases. From the kinetic experiments, hydrolytic DNA\u2010cleavage rate constants were determined as 1.54 for\n                    <jats:bold>1<\/jats:bold>\n                    and 0.72\u2005h\n                    <jats:sup>\u22121<\/jats:sup>\n                    for\n                    <jats:bold>2<\/jats:bold>\n                    . The nuclease activities of\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    are significant, giving rise to (2.03\u20132.88)\u00d710\n                    <jats:sup>7<\/jats:sup>\n                    \u2010fold rate enhancement compared to non\u2010catalyzed DNA cleavage.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.201000153","type":"journal-article","created":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T05:48:52Z","timestamp":1310968132000},"page":"1245-1265","source":"Crossref","is-referenced-by-count":33,"title":["Synthesis, Characterization, and DNA\u2010Binding and \u2010Cleavage Properties of Dinuclear Cu\n                    <sup>II<\/sup>\n                    \uf8ffSalophen\/Salen Complexes"],"prefix":"10.1002","volume":"8","author":[{"given":"Pulimamidi","family":"Rabindra\u2005Reddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Addla","family":"Shilpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,18]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.01.001"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/156801105774574694"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2006.05.002"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr000253a"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr960436q"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr950042j"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr950043b"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2004.12.016"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199612191"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2006.02.010"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja020039z"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja012539i"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/B313634E"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2007.11.008"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-004-0529-0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11243-005-4050-2"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(99)00043-0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1039\/b301099f"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10947-009-0007-1"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic960196x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00056a009"},{"key":"e_1_2_1_22_2","volume":"64","author":"Yu G.","year":"2008","journal-title":"Acta Crystallogr., Sect. 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