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Here, we examined the <jats:italic>in vitro<\/jats:italic> effects of dermaseptin 01 (DS\u200501), an antimicrobial peptide found in the skin secretion of frogs of the genus <jats:italic>Phyllomedusa<\/jats:italic>, on <jats:italic>Schistosoma mansoni<\/jats:italic> adult worms. DS\u200501 at a concentration of 100\u2005\u03bcg\/ml reduced the worm motor activity and caused the death of all worms within 48\u2005h in <jats:italic>RPMI 1640<\/jats:italic> medium. At the highest sublethal concentration of antimicrobial peptide (75\u2005\u03bcg\/ml), a 100% reduction in egg output of paired female worms was observed. Additionally, DS\u200501 induced morphological alterations on the tegument of <jats:italic>S. mansoni<\/jats:italic>, and a quantitative analysis carried out by confocal microscopy revealed extensive destruction of the tubercles in a dose\u2010dependent manner over the concentration range of 50\u2013200\u2005\u03bcg\/ml. It was the first time that an anthelmintic activity towards schistosomes has been reported for a dermaseptin.<\/jats:p>","DOI":"10.1002\/cbdv.201000163","type":"journal-article","created":{"date-parts":[[2011,3,14]],"date-time":"2011-03-14T11:52:30Z","timestamp":1300103550000},"page":"548-558","source":"Crossref","is-referenced-by-count":38,"title":["Evaluation of the <i>in vitro<\/i> Activity of Dermaseptin 01, a Cationic Antimicrobial Peptide, against <i>Schistosoma mansoni<\/i>"],"prefix":"10.1002","volume":"8","author":[{"given":"Josu\u00e9","family":"de\u2005Moraes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiz M. C. V.","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 R. S. 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