{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:18:44Z","timestamp":1790011124818,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T00:00:00Z","timestamp":1339718400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The addition of epigenetic modifying agents and ion\u2010exchange resins to culture media and solid\u2010state fermentations have been promoted as ways to stimulate expression of latent biosynthetic gene clusters and to modulate secondary metabolite biosynthesis. We asked how combination of these treatments would affect a population of screening isolates and their patterns of antibiosis relative to fermentation controls. A set of 43 <jats:italic>Emericella<\/jats:italic> strains, representing 25 species and varieties, were grown on a nutrient\u2010rich medium comprising glucose, casein hydrolysate, urea, and mineral salts. Each strain was grown in untreated agitated liquid medium, a medium treated with suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, 5\u2010azacytidine, a DNA methylation inhibitor, an <jats:italic>Amberlite<\/jats:italic> non\u2010ionic polyacrylate resin, and the same medium incorporated into an inert static vermiculite matrix. Species\u2010inherent metabolic differences more strongly influenced patterns of antibiosis than medium treatments. The antibacterial siderophore, desferritriacetylfusigen (<jats:bold>1<\/jats:bold>), was detected in most species in liquid media, but not in the vermiculite medium. The predominant antifungal component detected was echinocandin B. Some species produced this antifungal regardless of treatment, although higher quantities were often produced in vermiculite. Several species are reported for the first time to produce echinocandin B (<jats:bold>3<\/jats:bold>). A new echinocandin analog, echinocandin E (<jats:bold>2<\/jats:bold>), was identified from <jats:italic>E. quadrilineata.<\/jats:italic><\/jats:p>","DOI":"10.1002\/cbdv.201100362","type":"journal-article","created":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T07:27:59Z","timestamp":1339745279000},"page":"1095-1113","source":"Crossref","is-referenced-by-count":31,"title":["Chemical and Physical Modulation of Antibiotic Activity in <i>Emericella<\/i> Species"],"prefix":"10.1002","volume":"9","author":[{"given":"Mercedes","family":"de\u2005la\u2005Cruz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Gonz\u00e1lez\u2010Men\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"P\u00e9rez\u2010Victoria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Rub\u00e9n","family":"Tormo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noureddine","family":"El\u2005Aouad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Guarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald F.","family":"Bills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,15]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2011.02327.x"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1439-7633(20020703)3:7<619::AID-CBIC619>3.0.CO;2-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2008.03735.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201000133"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.46.535"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2007.61"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-006-0088-1"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/b821578b"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol1027199"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-009-0678-9"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/b920860g"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002530000565"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7915.2010.00196.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.5598\/imafungus.2010.01.02.13"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.funbio.2011.02.013"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3852\/08-078"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04341"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02000-10"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2010.06.003"},{"key":"e_1_2_1_20_2","first-page":"22","volume":"39","author":"Dreyfuss M. M.","year":"1986","journal-title":"Sydowia"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19740570818"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-770-5"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1967.tb19518.x"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2007.01.013"},{"key":"e_1_2_1_25_2","unstructured":"J. Buckingham \u2018Dictionary of Natural Products on DVD\u2019 CRC Press Boca Raton USA 2011."},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1128\/aem.47.6.1323-1326.1984","volume":"47","author":"Evans P. J.","year":"1984","journal-title":"Appl. Environ. Microbiol."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.30.125"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.31.1110"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00446522"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.1.2.94"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1081\/AL-120034063"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.4.2338-2343.2000"},{"key":"e_1_2_1_33_2","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1128\/aem.55.10.2720-2722.1989","volume":"55","author":"Fekete F. A.","year":"1989","journal-title":"Appl. Environ. Microbiol."},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo016088w"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/np50100a018"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1177\/108705719900400206"},{"key":"e_1_2_1_37_2","first-page":"133","volume":"59","author":"Bills G. F.","year":"2009","journal-title":"Soc. Ind. Microbiol. News"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycres.2009.02.011"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbdv.201100362","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.201100362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:06:44Z","timestamp":1700568404000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.201100362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1002\/cbdv.201100362"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.201100362","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}