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Even though its structure was determined in 2000 by powder X\u2010ray diffraction, significant questions remain about its formation and possible interaction with quinoline antimalarial drugs. A recent structural study, also with X\u2010ray powder diffraction, has reconfirmed that the material isolated from the parasite is isostructural with its synthetic equivalent. It was recently suggested that other isomers may also be formed and may be present in synthetic samples. In particular, a series of stereoisomers are possible for the arrangement of vinyl groups on the periphery of the dimerized porphyrin rings. In principle, any given dimer can have vinyl groups at the <jats:italic>\u03b1<\/jats:italic> or <jats:italic>\u03b2<\/jats:italic> sites, and at <jats:italic>\u03b3<\/jats:italic> or <jats:italic>\u03b4<\/jats:italic> sites. In this paper, several models are evaluated, both biphasic and homogeneous methyl\/vinyl disorder, against several sets of diffraction data, both published and new. We conclude that methyl\/vinyl disorder is intrinsic to the system, and that the evidence at hand does not support the existence of any other crystalline isomers in carefully prepared samples of either natural or synthetic samples. Finally, the porphyrin\uf8ffporphyrin interactions are evaluated using <jats:italic>Scheidt<\/jats:italic>'s indicies for porphyrin <jats:italic>\u03c0<\/jats:italic>\u2010stacking, and we find modest to weak <jats:italic>\u03c0<\/jats:italic>\u2010interactions in these condensed phases.<\/jats:p>","DOI":"10.1002\/cbdv.201200033","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T13:56:45Z","timestamp":1347544605000},"page":"1891-1902","source":"Crossref","is-referenced-by-count":33,"title":["Structure of Malaria Pigment and Related Propanoate\u2010Linked Metalloporphyrin Dimers"],"prefix":"10.1002","volume":"9","author":[{"given":"D. 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